Antineoplastic drugs (ADs) are widely used in cancer treatment. Nurses in chemotherapy centers are exposed to these drugs during preparation. They can affect healthy cells, leading to teratogenic and mutagenic effects, as well as oxidative stress. This study aimed to evaluate oxidative stress biomarkers in the nurses exposed to these drugs. This study was conducted on 30 nurses exposed to ADs and 30 nurses with no exposure to these drugs as non-exposed group. Oxidative stress biomarkers were measured in the blood serum samples of both groups, including malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity (TAC), and blood thiol groups. Considering the possibility of confounding effect of nutritional supplement consumption, the effect of this factor was adjusted in the analysis. A significant difference was observed for CAT, SOD, thiol, and TAC biomarkers between two groups (P < 0.05). However, the difference in MDA and GPx biomarkers between two groups was not statistically significant. The findings of the present study showed that supplement consumption has a significant effect on the biomarker of total antioxidant capacity. Thus, total antioxidant capacity measurement is advised as the best biomarker for tracking oxidative status in nurses exposed to ADs due to its capacity to measure all antioxidants in the body, except the thiol group, and its lower cost when compared to other biomarkers. Furthermore, it can be claimed that the consumption of nutritional supplements has a greater effect on the non-enzymatic biomarkers of oxidative stress than on enzymatic antioxidant system.

中文翻译：

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评估接触抗肿瘤药物的肿瘤科护士的氧化应激生物标志物：一项横断面研究

抗肿瘤药物（AD）广泛用于癌症治疗。化疗中心的护士在准备过程中会接触这些药物。它们会影响健康细胞，导致致畸和致突变作用以及氧化应激。本研究旨在评估接触这些药物的护士的氧化应激生物标志物。这项研究对 30 名接触过 AD 的护士和 30 名未接触过这些药物的护士作为非接触组进行。检测两组血清样本中的氧化应激生物标志物，包括丙二醛（MDA）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、总抗氧化能力（TAC）和血硫醇组。考虑到营养补充剂摄入可能产生混杂效应，分析中对该因素的影响进行了调整。两组间 CAT、SOD、硫醇和 TAC 生物标志物存在显着差异（P < 0.05）。然而，两组间MDA和GPx生物标志物差异无统计学意义。本研究的结果表明，补充剂的摄入量对总抗氧化能力的生物标志物有显着影响。因此，总抗氧化能力测量被建议作为跟踪暴露于 AD 的护士氧化状态的最佳生物标志物，因为它能够测量体内除硫醇基团之外的所有抗氧化剂，并且与其他生物标志物相比成本较低。此外，可以说，营养补充剂的消耗对氧化应激的非酶生物标志物的影响比对酶抗氧化系统的影响更大。