Abstract The microbiome plays a critical role in the process of conception and the outcomes of pregnancy. Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications, which significantly impact maternal and fetal health. Recent studies have associated the microbiome in the female reproductive tract (FRT) with assisted reproductive technology (ART) outcomes, and restoring microbiome balance has been shown to improve fertility in infertile couples. This review provides an overview of the role of the microbiome in female reproductive health, including its implications for pregnancy outcomes and ARTs. Additionally, recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized. A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health. Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.

中文翻译：

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女性生殖健康中的微生物组：对生育和辅助生殖技术的影响

摘要微生物组在受孕过程和妊娠结果中起着至关重要的作用。育龄妇女微生物组稳态的破坏可能导致各种妊娠并发症，从而严重影响孕产妇和胎儿的健康。最近的研究将女性生殖道 (FRT) 中的微生物组与辅助生殖技术 (ART) 的结果联系起来，并且恢复微生物组平衡已被证明可以提高不孕夫妇的生育能力。本综述概述了微生物组在女性生殖健康中的作用，包括其对妊娠结局和辅助生殖技术的影响。此外，还总结了使用微生物生物标志物作为妊娠疾病指标的最新进展。全面了解孕前和孕期微生物群的特征及其对生殖健康的影响将极大地促进母婴健康。这些知识还可以促进 ART 和基于微生物组的干预措施的发展。