Recent studies have highlighted a connection between gut microbiota and hypertension, yet the precise nature of this relationship remains unclear. This research aims to analyze the causal link between gut microbiota and hypertension, along with associated complications, utilizing two-sample bidirectional Mendelian randomization (MR). Summary data from genome-wide association studies (GWAS) meta-analyses, including gut microbiota GWAS data from 24 cohorts, and the latest GWAS data for hypertension-related conditions were acquired. Employing various MR methods, including Inverse-variance weighted (IVW), MR-Egger, Weighted Median, Simple Mode, and Weighted Mode, we investigated the association between gut microbiota and hypertension-related conditions. Sensitivity analyses were conducted for result stability, and reverse MR analysis assessed the potential for reverse causality. The Mendelian randomization analysis involving 199 microbial taxa and four phenotypes identified 46 microbial taxa with potential causal links to hypertension and its complications. Following Bonferroni correction, showed a robust causal relationship with hypertension (OR = 1.08, 95% CI = 1.04-1.12, P = 9.82e-5). This suggests an 8% increased risk of hypertension with each unit rise in abundance. In conclusion, this study establishes a causal connection between gut microbiota and hypertension, along with common associated complications. The findings unveil potential targets and evidence for future hypertension and complication treatment through gut microbiota interventions, offering a novel avenue for therapeutic exploration.

中文翻译：

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肠道菌群与高血压及高血压相关并发症之间的因果关系：双向双样本孟德尔随机分析

最近的研究强调了肠道微生物群与高血压之间的联系，但这种关系的确切性质仍不清楚。本研究旨在利用两个样本双向孟德尔随机化 (MR) 分析肠道微生物群与高血压之间的因果关系以及相关并发症。获取了全基因组关联研究 (GWAS) 荟萃分析的摘要数据，包括来自 24 个队列的肠道微生物 GWAS 数据以及高血压相关疾病的最新 GWAS 数据。我们采用各种 MR 方法，包括逆方差加权 (IVW)、MR-Egger、加权中位数、简单模式和加权模式，研究了肠道微生物群与高血压相关疾病之间的关联。为结果稳定性进行了敏感性分析，反向 MR 分析评估了反向因果关系的可能性。涉及 199 个微生物类群和四种表型的孟德尔随机化分析确定了 46 个与高血压及其并发症具有潜在因果关系的微生物类群。经过 Bonferroni 校正后，显示与高血压存在强有力的因果关系（OR = 1.08，95% CI = 1.04-1.12，P = 9.82e-5）。这表明每增加一个单位，患高血压的风险就会增加 8%。总之，这项研究建立了肠道微生物群与高血压以及常见相关并发症之间的因果关系。这些发现揭示了未来通过肠道微生物群干预治疗高血压和并发症的潜在目标和证据，为治疗探索提供了新途径。