Understanding the immune response to , a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to , with different subsets having distinct functions. Th1 cells are important for controlling fungal growth, while Th2 cells can exacerbate infection. Th17 cells promote the clearance of fungi indirectly by stimulating the production of various antimicrobial peptides from epithelial cells and directly by recruiting and activating neutrophils. Regulatory T cells have varied functions in infection. They expand after exposure to conidia and prevent organ injury and fungal sepsis by downregulating inflammation and inhibiting neutrophils or suppressing Th17 cells. Regulatory T cells also block Th2 cells to stop aspergillosis allergies. Immunotherapy with CAR T cells is a promising treatment for fungal infections, including infections, especially in immunocompromised individuals. However, further research is needed to fully understand the mechanisms underlying the immune response to and to develop effective immunotherapies with CAR-T cells for this infection. This literature review explores the role of Tcell subsets in infection, and the effects of CAR-T cell therapy on this fungal infection.

中文翻译：

---

T细胞亚群和CAR-T细胞治疗在烟曲霉感染中作用的全面综述

真菌感染是免疫功能低下个体侵袭性真菌感染 (IFI) 的常见原因，了解其免疫反应对于开发有效的治疗方法至关重要。T细胞在免疫反应中发挥着关键作用，不同的亚群具有不同的功能。Th1 细胞对于控制真菌生长很重要，而 Th2 细胞会加剧感染。Th17 细胞通过刺激上皮细胞产生各种抗菌肽来间接促进真菌的清除，并通过招募和激活中性粒细胞来直接促进真菌的清除。调节性 T 细胞在感染中具有多种功能。它们在接触分生孢子后会扩张，并通过下调炎症和抑制中性粒细胞或抑制 Th17 细胞来预防器官损伤和真菌败血症。调节性 T 细胞还可以阻断 Th2 细胞以阻止曲霉病过敏。CAR T 细胞免疫疗法是治疗真菌感染（包括感染）的一种有前途的治疗方法，特别是对于免疫功能低下的个体。然而，还需要进一步的研究来充分了解免疫反应的机制，并开发针对这种感染的 CAR-T 细胞的有效免疫疗法。本文献综述探讨了 T 细胞亚群在感染中的作用，以及 CAR-T 细胞治疗对该真菌感染的影响。