Bacterial cellulose (BC) has emerged as a promising biomaterial for rapid wound healing and tissue regeneration due to its excellent liquid absorbing and biocompatible properties. However, its lack of therapeutic properties restricts its applicability as a wound dressing. The current study was undertaken to develop bacterial cellulose-turmeric powder (BC-TP) composite films as wound dressing materials that combine the therapeutic properties of turmeric powder (TP) with the unique structural, physicochemical, and biological properties of BC. FTIR and SEM showed that TP was successfully impregnated into BC films using an approach. Swelling and water release rate studies revealed that the composite films produced had high-water uptake and retention capacities. Antibacterial investigations using gram-positive and -negative species demonstrated the significant antibacterial potential of TP when incorporated into a BC matrix. Toxicity testing confirmed the non-cytotoxic nature of BC-TP composite films, while biocompatibility investigations demonstrated that fibroblast cells attached and proliferated effectively on BC films treated with TP. Furthermore, BC-TP composites promoted tissue regeneration, hair growth, and wound healing. BC composites exhibited over 90% wound closure by the 7th day, whereas untreated wounds demonstrated only approximately 24% closure during the same period. The study shows that the manufactured BC-TP composite films offer starting points for the development of alternative standard wound dressing systems.

中文翻译：

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细菌纤维素-姜黄粉复合材料作为潜在的治疗性伤口敷料

细菌纤维素（BC）由于其优异的液体吸收和生物相容性特性，已成为一种有前途的生物材料，可用于快速伤口愈合和组织再生。然而，其缺乏治疗特性限制了其作为伤口敷料的应用。目前的研究旨在开发细菌纤维素-姜黄粉（BC-TP）复合膜作为伤口敷料材料，将姜黄粉（TP）的治疗特性与BC独特的结构、理化和生物学特性相结合。FTIR 和 SEM 显示，TP 已成功浸渍到 BC 薄膜中。溶胀和水释放速率研究表明，所生产的复合薄膜具有高吸水和保留能力。使用革兰氏阳性和阴性物种进行的抗菌研究表明，当将 TP 纳入 BC 基质时，其具有显着的抗菌潜力。毒性测试证实了BC-TP复合膜的非细胞毒性，而生物相容性研究表明成纤维细胞在经过TP处理的BC膜上有效附着和增殖。此外，BC-TP 复合材料还能促进组织再生、毛发生长和伤口愈合。BC 复合材料在第 7 天时表现出超过 90% 的伤口闭合，而未经治疗的伤口在同一时期仅表现出约 24% 的闭合。研究表明，制造的 BC-TP 复合薄膜为开发替代标准伤口敷料系统提供了起点。