Doxycycline post exposure prophylaxis (PEP) has been shown to reduce the incidence of bacterial STIs. However, if there is genetic linkage between resistance to tetracycline and other antimicrobials, then it could also select for resistance to these other antimicrobials. We therefore undertook to evaluate if there is an association between the minimum inhibitory concentrations (MICs) of tetracycline and other antimicrobials in 19 clinically important bacterial species. Mixed-effects linear regression was used to assess if minocycline MICs were associated with the MICs of eight other antimicrobials (ceftriaxone, ampicillin, oxacillin, vancomycin, erythromycin, levofloxacin, amikacin, and trimethoprim-sulfamethoxazole) in 19 bacterial species in the Antimicrobial Testing Leadership and Surveillance (ATLAS) database. With the notable exception of vancomycin, where no association was found, strong positive associations were typically found between the MICs of minocycline and each of the eight antimicrobials in each of the species assessed. For example, the minocycline MICs of all the Gram-positive species were positively associated with ampicillin, ceftriaxone, oxacillin and erythromycin MICs (all -values < 0.001). The only exceptions were ampicillin for and ceftriaxone for where no significant associations were found. Similarly in the Gram-negative species, the minocycline MICs of all the species except and were positively associated with the MICs of ceftriaxone, ampicillin, levofloxacin and amikacin (all -values < 0.001). There is a theoretical risk that doxycycline PEP could select for resistance not only to tetracyclines but to a range of other antimicrobials in each of the 19 pathobionts assessed.

中文翻译：

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理论上，多西环素暴露后预防可以选择 19 种病原体对各种抗菌药物的耐药性：计算机分析

强力霉素暴露后预防 (PEP) 已被证明可以减少细菌性传播感染的发生率。然而，如果对四环素和其他抗菌药物的耐药性之间存在遗传联系，那么它也可能选择对这些其他抗菌药物产生耐药性。因此，我们着手评估四环素和其他抗菌药物对 19 种临床重要细菌的最低抑菌浓度 (MIC) 之间是否存在关联。使用混合效应线性回归评估米诺环素 MIC 是否与其他 8 种抗菌药物（头孢曲松、氨苄青霉素、苯唑西林、万古霉素、红霉素、左氧氟沙星、阿米卡星和甲氧苄氨嘧啶-磺胺甲恶唑）在 19 种细菌中的 MIC 相关。和监视（ATLAS）数据库。除了万古霉素没有发现关联之外，米诺环素与所评估的每个物种中八种抗菌药物的 MIC 之间通常存在强正相关。例如，所有革兰氏阳性菌的米诺环素 MIC 与氨苄西林、头孢曲松、苯唑西林和红霉素 MIC 呈正相关（所有值均 < 0.001）。唯一的例外是氨苄青霉素和头孢曲松，未发现显着关联。同样，在革兰氏阴性物种中，除头孢曲松、氨苄西林、左氧氟沙星和阿米卡星外，所有物种的米诺环素 MIC 均与头孢曲松、氨苄青霉素、左氧氟沙星和阿米卡星的 MIC 呈正相关（所有值均 < 0.001）。理论上存在这样的风险：强力霉素 PEP 可能不仅对四环素产生耐药性，而且对所评估的 19 种病原体中的每一种都产生对一系列其他抗菌药物的耐药性。