Psoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the ‘skin-brain axis’. Understanding the mechanisms underlying psoriasis and psychiatric comorbidities can help improve the efficacy of treatment by breaking the vicious cycle of diseases.

中文翻译：

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T 细胞介导的皮肤-大脑轴：弥合银屑病和精神合并症之间的差距

牛皮癣是一种慢性炎症性皮肤病，通常伴有精神合并症，如焦虑、抑郁、自杀意念和其他精神障碍。心理障碍也可能在牛皮癣的发生和进展中发挥作用。皮肤病和精神合并症之间错综复杂的相互作用是由“皮肤-大脑轴”介导的。了解牛皮癣和精神合并症的潜在机制有助于打破疾病的恶性循环，从而提高治疗效果。