Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role. The objective of the current work was to study the association between muscle mass, determined via bioelectrical impedance (BIA), and circulating adiponectin levels among obese patients with metabolic syndrome who are older than 60 years of age. We performed a cross-sectional study incorporating 651 patients with obesity and metabolic syndrome. Anthropometric data, BIA data (total fat mass (FM), fat-free mass (FFM), fat-free mass index (FFMi), skeletal muscle mass (SMM) and skeletal muscle mass index (SMMi)), arterial pressure, HOMA-IR (homeostasis model assessment of insulin resistance), and biochemical parameters were recorded. The patients were separated into two groups based on their median SMMi (skeletal muscle mass index) levels. The low-SMMi group presented adiponectin levels that were higher than those in the high-SMMi group (delta value: 4.8 + 0.7 ng/dl: = 0.02). Serum adiponectin values were negatively correlated with fat mass (FM), fat-free mass (FFM), fat-free mass index (FFMi), SMM, and SMMi. Adiponectin presented a negative correlation with HOMA-IR and a positive correlation with HDL-cholesterol. In the final multivariate model using SMMi as a dependent variable, adiponectin levels explained 18 % of the variability (Beta −0.49, CI95% −0.89 to −0.16) after adjusting for age and gender. Serum adiponectin levels are negatively associated with low skeletal muscle mass among obese subjects with metabolic syndrome who are older than 60 years of age.

中文翻译：

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代谢综合征合并肥胖患者脂联素与肌肉质量的关系

脂联素是人类最重要的脂肪因子之一。肥胖和肌肉减少症与低水平的慢性炎症状态有关，脂联素具有抗炎作用。当前工作的目的是研究 60 岁以上患有代谢综合征的肥胖患者的肌肉质量（通过生物电阻抗 (BIA) 测定）与循环脂联素水平之间的关系。我们进行了一项横断面研究，纳入了 651 名患有肥胖和代谢综合征的患者。人体测量数据、BIA数据（总脂肪质量（FM）、去脂质量（FFM）、去脂质量指数（FFMi）、骨骼肌质量（SMM）和骨骼肌质量指数（SMMi））、动脉压、HOMA -IR（胰岛素抵抗的稳态模型评估）和生化参数被记录。根据患者中位 SMMi（骨骼肌质量指数）水平将患者分为两组。低 SMMi 组的脂联素水平高于高 SMMi 组（δ 值：4.8 + 0.7 ng/dl：= 0.02）。血清脂联素值与脂肪质量（FM）、去脂质量（FFM）、去脂质量指数（FFMi）、SMM和SMMi呈负相关。脂联素与 HOMA-IR 呈负相关，与 HDL-胆固醇呈正相关。在使用 SMMi 作为因变量的最终多变量模型中，在调整年龄和性别后，脂联素水平解释了 18% 的变异性（Beta -0.49，CI95% -0.89 至 -0.16）。 60 岁以上患有代谢综合征的肥胖受试者中，血清脂联素水平与低骨骼肌质量呈负相关。