Dengue represents a major public health problem in the Americas in general, and in Posadas (Misiones, Argentina) in particular. This study aimed to assess the seroprevalence of dengue virus infection, analyze associated factors, and determine the proportion of asymptomatic cases. This prospective cross-sectional study took place from November 2017 to April 2019 in the High Complexity Laboratory of Misiones, at the School Hospital Dr. Ramón Madariaga in Posadas. A random sample of 301 adults (≥ 15 years) was selected from the electoral registry and stratified by geographical area of residence. Sociodemographic, clinical, and laboratory data were collected by means of a survey and serology. Results were analyzed using multivariable logistic regression. The median age of the sample was 33 years; 66% were women, and 46.5% had completed at least secondary school. Anti-dengue IgG antibodies were present in 40.2% of the sample (95% confidence interval [CI] 34.5–45.9%), including 90% of those who reported dengue and 20.5% who did not (odds ratio [OR] 33.25, 95% CI 15.46–71.51, p < 0.001). In the multivariable analysis, adjusted for age, group, gender, and vaccination against yellow fever, seropositivity was associated with having relatives with dengue (adjusted OR 3.96, 95% CI 2.18–7.23; p < 0.001). Seroprevalence for dengue in Posadas was higher than estimates based on the notification records, and there was a high proportion of asymptomatic cases. Educational level and having a family member who had suffered from dengue were associated with positive serology.

中文翻译：

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2017-2019 年波萨达斯（阿根廷米西奥内斯省）有症状和无症状成人登革热 IgG 血清阳性率及相关危险因素

登革热是整个美洲的一个主要公共卫生问题，特别是在波萨达斯（阿根廷米西奥内斯省）。本研究旨在评估登革热病毒感染的血清流行率，分析相关因素，并确定无症状病例的比例。这项前瞻性横断面研究于 2017 年 11 月至 2019 年 4 月在波萨达斯 Ramón Madariaga 博士学校医院米西奥内斯高复杂性实验室进行。从选举登记册中随机抽取 301 名成年人（≥ 15 岁）作为样本，并按居住地理区域进行分层。通过调查和血清学收集社会人口统计学、临床和实验室数据。使用多变量逻辑回归分析结果。样本的平均年龄为 33 岁； 66% 是女性，46.5% 至少完成了中学学业。 40.2% 的样本中存在抗登革热 IgG 抗体（95% 置信区间 [CI] 34.5–45.9%），其中 90% 报告登革热，20.5% 未报告登革热（比值比 [OR] 33.25, 95） % CI 15.46–71.51，p < 0.001）。在多变量分析中，根据年龄、群体、性别和黄热病疫苗接种进行调整后，血清阳性与亲属患有登革热相关（调整后 OR 3.96，95% CI 2.18–7.23；p < 0.001）。波萨达斯的登革热血清流行率高于根据通报记录估计的值，而且无症状病例的比例很高。教育水平和家庭成员患有登革热与血清学阳性有关。