This systematic review aims to analyze the existing literature investigating respiratory functioning in people with Persistent Somatic Symptoms (PSS) compared to healthy controls, to identify patterns of respiratory disturbances by symptom or syndrome, and describe any respiratory outcomes consistent across diagnoses. A systematic review following PRISMA guidelines was conducted. A comprehensive search was carried out across five databases (PubMed (NCBI), PsycArticles (Ovid), Web of Science (Core Collection), Embase, and Scopus) using two customised search strings for persistent somatic symptoms and objective respiratory parameters. Title/abstract screening and data extraction were carried out independently by two reviewers. The modified Newcastle-Ottawa Scale was used for quality assessment of the studies. Studies investigating baseline respiratory functioning in adult patients with PSS compared to healthy controls, using at least one objective respiratory were included. 18 studies met the inclusion criteria for the review, with a pooled sample size of 3245. Chronic pain conditions were found to be the most prevalent subset of diagnoses of interest, comprising six of the studies. 10 studies included measures of lung capacity, flow and/or volume, nine studies reported measures of ventilation, and four studies investigated respiratory muscle functioning. 13 of the included studies reported significant differences in at least one objective respiratory measure between groups (at rest). Scores on self-reported measures of dysnpea and breathlessness were higher in patients compared to healthy controls, while objective respiratory outcomes were varied. The current systematic review is consistent with previous literature suggesting more pronounced experiences of breathlessness in patients with PSS, and significant disparities between reported dyspnea and objective respiratory outcomes. Research investigating the uncoupling between subjective and objective respiratory outcomes is needed to understand the mechanisms behind breathing disturbances in PSS.

中文翻译：

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持续性躯体症状中的呼吸功能障碍：观察性研究的系统回顾

本系统综述旨在分析现有文献，调查持续性躯体症状 (PSS) 患者与健康对照组相比的呼吸功能，通过症状或综合征识别呼吸紊乱模式，并描述与诊断一致的任何呼吸结果。遵循 PRISMA 指南进行了系统审查。使用两个针对持续性躯体症状和客观呼吸参数的定制搜索字符串，在五个数据库（PubMed (NCBI)、PsycArticles (Ovid)、Web of Science（核心合集）、Embase 和 Scopus）中进行了全面搜索。标题/摘要筛选和数据提取由两名评审员独立进行。修改后的纽卡斯尔-渥太华量表用于研究的质量评估。其中包括使用至少一种客观呼吸系统来调查成年 PSS 患者与健康对照者基线呼吸功能的研究。18 项研究符合该评价的纳入标准，合并样本量为 3245。发现慢性疼痛是感兴趣的诊断中最常见的子集，其中包括 6 项研究。10 项研究包括肺活量、流量和/或容量的测量，9 项研究报告了通气量的测量，4 项研究调查了呼吸肌功能。其中 13 项纳入的研究报告称，各组之间（休息时）至少一项客观呼吸测量指标存在显着差异。与健康对照相比，患者自我报告的呼吸困难和呼吸困难测量得分较高，但客观呼吸结果各不相同。目前的系统评价与之前的文献一致，表明 PSS 患者有更明显的呼吸困难经历，并且报告的呼吸困难与客观呼吸结果之间存在显着差异。需要研究主观和客观呼吸结果之间的脱钩，以了解 PSS 呼吸障碍背后的机制。