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A novel perspective on eugenol as a natural anti-quorum sensing molecule against Serratia sp.
Microbial Pathogenesis ( IF 3.8 ) Pub Date : 2024-02-20 , DOI: 10.1016/j.micpath.2024.106576
Fakher Frikha , Marwa Jardak , Sami Aifa , Sami Mnif

is commonly noted to be an opportunistic pathogen and is often associated with nosocomial infections. In addition to its high antibiotic resistance, it exhibits a wide range of virulence factors that confer pathogenicity. Targeting quorum sensing (QS) presents a potential therapeutic strategy for treating bacterial infections caused by , as it regulates the expression of various virulence factors. Inhibiting QS can effectively neutralize bacterial virulence without exerting stress on bacterial growth, facilitating bacterial eradication by the immune system. In this study, the antibacterial and anti-virulence properties of eugenol against sp. were investigated.

中文翻译:

关于丁子香酚作为对抗沙雷氏菌的天然抗群体感应分子的新视角。

通常被认为是一种机会性病原体,通常与医院感染有关。除了其高抗生素耐药性之外,它还表现出多种具有致病性的毒力因子。靶向群体感应(QS)为治疗由 引起的细菌感染提供了一种潜在的治疗策略,因为它调节各种毒力因子的表达。抑制QS可以有效中和细菌毒力,而不会对细菌生长造成压力,有利于免疫系统消灭细菌。在这项研究中,丁子香酚对细菌的抗菌和抗毒力特性。被调查。
更新日期:2024-02-20
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