Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.

中文翻译：

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SARS-CoV-2感染急性后遗症外周血单核细胞线粒体呼吸的改变

测量了无 COVID 病史的参与者 (n = 19)、有 COVID 病史且完全康复的参与者 (n = 20) 以及有 PASC 的参与者 (n = 20) 的外周血单核细胞 (PBMC) 线粒体呼吸。平均线粒体基础呼吸、ATP 相关呼吸、最大呼吸、备用呼吸能力、ATP 相关呼吸和非线粒体呼吸在 COVID + PASC+ 中最高 (p ≤ 0.04)。非线粒体呼吸、ATP 相关呼吸、基础呼吸、备用呼吸能力和最大呼吸每增加一个单位，PASC 的预测几率就会增加 1% 到 6%。PBMC 中的线粒体功能障碍可能是 PASC 的病因之一。