Childhood adversity is associated with poor cardiometabolic health in adulthood; little is known about how this relationship evolves through childbearing years for parous individuals. The goal was to estimate differences in cardiometabolic health indicators before, during and after childbearing years by report of childhood maltreatment in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study. Including 743 individuals nulliparous at baseline (1985–1986) with one or more pregnancies >20 weeks during follow-up (1986–2022), we fit segmented linear regression models to estimate mean differences between individuals reporting or not reporting childhood maltreatment (physical or emotional) in waist circumference, triglycerides, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, fasting glucose, and body mass index (BMI) prior to, during, and following childbearing years using generalized estimating equations, allowing for interaction between maltreatment and time within each segment, and adjusting for total parity, parental education, and race (Black or white, self-reported). Individuals reporting maltreatment (19%; 141) had a greater waist circumference (post-childbearing: +2.9 cm, 95% CI (0.7, 5.0), higher triglycerides [post-childbearing: +8.1 mg/dL, 95% CI (0.7, 15.6)], and lower HDL cholesterol [post-childbearing: −2.1 mg/dL, 95% CI (−4.7, 0.5)] during all stages compared to those not reporting maltreatment. There were not meaningful differences in blood pressure, fasting glucose, or BMI. Individuals who reported maltreatment did not report faster changes over time. Differences in some aspects of cardiometabolic health between individuals reporting versus not reporting childhood maltreatment were sustained across reproductive life stages, suggesting potentially persistent impacts of childhood adversity.

中文翻译：

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年轻人冠状动脉风险发展研究期间第一胎个体的童年虐待和整个生殖寿命期间心脏代谢健康的轨迹

童年时期的逆境与成年后心脏代谢健康状况不佳有关；对于已婚个体在育龄期间这种关系如何演变，我们知之甚少。目标是通过年轻人冠状动脉风险发展 (CARDIA) 队列研究中儿童虐待的报告来估计育龄前、育龄期间和育龄后心脏代谢健康指标的差异。包括 743 名基线时（1985-1986 年）未生育且在随访期间（1986-2022 年）有一次或多次妊娠超过 20 周的个体，我们拟合分段线性回归模型来估计报告或未报告儿童期虐待（身体或虐待）的个体之间的平均差异。使用广义估计方程，在腰围、甘油三酯、高密度脂蛋白胆固醇、收缩压和舒张压、空腹血糖和育龄前、育龄期间和育龄后的体重指数（BMI）方面进行研究，考虑到虐待和虐待之间的相互作用每个部分的时间，并根据总平等、父母教育和种族（黑人或白人，自我报告）进行调整。报告遭受虐待的个体 (19%; 141) 腰围较大（生育后：+2.9 cm，95% CI (0.7, 5.0)，甘油三酯较高 [生育后：+8.1 mg/dL，95% CI (0.7) , 15.6)]，并且与那些未报告虐待的人相比，所有阶段的 HDL 胆固醇水平都较低 [生育后：-2.1 mg/dL，95% CI (-4.7, 0.5)]。血压、禁食没有显着差异报告虐待行为的个体并没有报告随着时间的推移发生更快的变化。报告与未报告童年虐待的个体之间心脏代谢健康的某些方面的差异在整个生殖生命阶段持续存在，这表明童年逆境可能产生持续的影响。