Demyelination stands out as a prominent feature in individuals with specific types of epilepsy. Concurrently, individuals with demyelinating diseases, such as multiple sclerosis (MS) are at a greater risk of developing epilepsy compared to non-MS individuals. These bidirectional connections raise the question of whether both pathological conditions share common pathogenic mechanisms. This review focuses on the reciprocal relationship between epilepsy and demyelination diseases. We commence with an overview of the neurological basis of epilepsy and demyelination diseases, followed by an exploration of how our comprehension of these two disorders has evolved in tandem. Additionally, we discuss the potential pathogenic mechanisms contributing to the interactive relationship between these two diseases. A more nuanced understanding of the interplay between epilepsy and demyelination diseases has the potential to unveiling the molecular intricacies of their pathological relationships, paving the way for innovative directions in future clinical management and treatment strategies for these diseases.

中文翻译：

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癫痫和脱髓鞘：走向双向关系

脱髓鞘是特定类型癫痫患者的一个突出特征。同时，与非 MS 个体相比，患有脱髓鞘疾病（例如多发性硬化症 (MS)）的个体患癫痫的风险更大。这些双向联系提出了这样的问题：两种病理状况是否具有共同的致病机制。本综述重点关注癫痫和脱髓鞘疾病之间的相互关系。我们首先概述癫痫和脱髓鞘疾病的神经学基础，然后探索我们对这两种疾病的理解是如何同步发展的。此外，我们还讨论了导致这两种疾病之间相互作用关系的潜在致病机制。对癫痫和脱髓鞘疾病之间相互作用的更细致的了解有可能揭示其病理关系的分子复杂性，为这些疾病的未来临床管理和治疗策略的创新方向铺平道路。