This study reported a tandem strategy on sequential base-controlled benzylation/Pd-catalyzed secondary amide arylation for one-pot synthesis of highly functionalized hydroquinolin-2-ones. This strategy involves creation of 3 bonds, 1 ring, and 1 quaternary carbon center while synthesizing diverse 3-cyano substituted hydroquinolin-2-ones in 41–83% yields.

中文翻译：

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通过串联苄基化/分子内 C-N 偶联策略合成高功能化二氢喹啉酮

本研究报道了连续碱基控制的苄基化/Pd 催化的仲酰胺芳基化的串联策略，用于一锅合成高功能化的氢喹啉-2-酮。该策略涉及创建 3 个键、1 个环和 1 个季碳中心，同时合成多种 3-氰基取代的氢喹啉-2-酮，产率为 41-83%。