While the sexual transmissibility of HAV in MSM has been extensively described, the potential for sexual transmission of HEV has not been definitively established. Although HEV has been detected in the ejaculate of chronically infected men, studies among MSM PrEP users in France did not observe an elevated anti-HEV seroprevalence as an indicator of increased exposure risk by sexual intercourse. A total of 111 unselected PrEP users and 111 age- and sex-matched blood donors were tested for anti-HEV IgG, IgM and HEV (PCR). Of the participants 79/111 (71 %) responded to a questionnaire covering topics as sexual preferences, previous sexually transmitted diseases, profession, food consumption, and pet ownership. The anti-HEV IgG seroprevalence in PrEP users (22 %) did not differ significantly from the rate in controls (17 %). While one PrEP user and three controls tested positive for anti-HEV IgM, all PrEP users and controls tested PCR negative. In immunocompetent individuals with frequent changes of sexual partners, the epidemiology of Hepatitis E Virus does not significantly involve the sexual transmission route.

中文翻译：

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缺乏证据表明急性 HEV 感染是一种性传播疾病：来自德国 PrEP 用户队列的数据

虽然男男性行为者中甲型肝炎病毒的性传播已被广泛描述，但乙型肝炎病毒性传播的可能性尚未明确确定。尽管在慢性感染男性的精液中检测到了 HEV，但对法国 MSM PrEP 使用者的研究并未观察到抗 HEV 血清阳性率升高作为性交接触风险增加的指标。总共 111 名未经选择的 PrEP 用户和 111 名年龄和性别匹配的献血者接受了抗 HEV IgG、IgM 和 HEV (PCR) 检测。 79/111 (71%) 的参与者回答了一份调查问卷，涵盖性取向、既往性传播疾病、职业、食物消费和宠物饲养等主题。 PrEP 用户中的抗 HEV IgG 血清阳性率 (22%) 与对照组的血清阳性率 (17%) 没有显着差异。虽然一名 PrEP 用户和三名对照者的抗 HEV IgM 检测结果呈阳性，但所有 PrEP 用户和对照者的 PCR 检测结果均呈阴性。在免疫功能正常且经常更换性伴侣的个体中，戊型肝炎病毒的流行病学并不显着涉及性传播途径。