Lung cancer, the leading cause of cancer-related deaths, presents significant challenges to patients due to its poor prognosis. Recent research has increasingly implicated circular RNAs in the development and progression of lung cancer. These circular RNAs have been found to impact various aspects of tumor behavior, including proliferation, metastasis, cell cycle regulation, apoptosis, cancer stem cells, therapy response, and the tumor microenvironment. One of the key mechanisms by which circular RNAs exert their influence is through their ability to act as miRNA sponges, sequestering microRNAs and preventing them from targeting other RNA molecules. Accumulating evidence suggests that circular RNAs can function as competing endogenous RNAs, affecting the expression of target mRNAs by sequestering microRNAs. Dysregulation of competing endogenous RNAs networks involving circular RNAs, microRNAs, and mRNAs leads to the aberrant expression of oncogenes and tumor suppressors involved in lung cancer pathogenesis. Understanding the dynamic interplay and molecular mechanisms among circular RNAs, microRNAs, and mRNAs holds great promise for advancing early diagnosis, personalized therapeutic interventions, and improved patient outcomes in lung cancer. Therefore, this study aims to provide an in-depth exploration of the executive roles of circular RNAs/microRNAs/ mRNAs interactions in lung cancer pathogenesis and their potential utility for diagnosing lung cancer, predicting patient prognosis, and guiding targeted therapies. By offering a comprehensive overview of the dysregulation of the axes as driving factors in lung cancer, we aim to pave the way for their translation into clinical practice in the future.

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circRNA/miRNA/mRNA相互作用作为肺癌生物学调控网络的功能意义

肺癌是癌症相关死亡的主要原因，由于其预后不良，给患者带来了重大挑战。最近的研究越来越多地表明环状RNA与肺癌的发生和进展有关。人们发现这些环状RNA会影响肿瘤行为的各个方面，包括增殖、转移、细胞周期调节、细胞凋亡、癌症干细胞、治疗反应和肿瘤微环境。环状 RNA 发挥影响的关键机制之一是通过它们充当 miRNA 海绵的能力，隔离 microRNA 并防止它们靶向其他 RNA 分子。越来越多的证据表明，环状 RNA 可以作为竞争性内源 RNA，通过隔离 microRNA 来影响靶标 mRNA 的表达。涉及环状RNA、微小RNA和mRNA的竞争性内源RNA网络的失调导致参与肺癌发病机制的癌基因和抑癌基因的异常表达。了解环状 RNA、microRNA 和 mRNA 之间的动态相互作用和分子机制为推进肺癌的早期诊断、个性化治疗干预和改善患者预后带来了巨大希望。因此，本研究旨在深入探讨环状RNA/microRNA/mRNA相互作用在肺癌发病机制中的执行作用及其在诊断肺癌、预测患者预后和指导靶向治疗方面的潜在用途。通过对轴失调作为肺癌驱动因素的全面概述，我们的目标是为其将来转化为临床实践铺平道路。