Purpose

This study retrospectively analyzes cases of diffuse midline glioma treated with radiotherapy, with the aim of investigating the prognosis of the tumor and its influencing factors.

Methods

From January 2018 to November 2022, we treated 64 patients who were pathologically diagnosed with diffuse midline glioma. Among them, 41 underwent surgical resection, and 23 underwent biopsy procedures. All patients received postoperative radiotherapy. We followed up with the patients to determine the overall survival rate and conducted univariate and multivariate analyses on relevant indicators.

Results

The median survival time for the entire patient group was 33.3 months, with overall survival rates of 92.9%, 75.4%, and 45.0% at 1 year, 2 years, and 3 years, respectively. Univariate and multivariate analyses indicated that older patients had a better prognosis.

Conclusion

Patient age is an independent prognostic factor for patients with diffuse midline glioma undergoing radiation therapy.

中文翻译：

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弥漫性中线胶质瘤的预后因素分析

目的

本研究回顾性分析弥漫性中线胶质瘤放疗的病例，旨在探讨肿瘤的预后及其影响因素。

方法

自2018年1月至2022年11月，我们治疗了64例经病理诊断为弥漫性中线胶质瘤的患者。其中，41例接受了手术切除，23例接受了活检。所有患者均接受术后放疗。我们对患者进行随访以确定总生存率，并对相关指标进行单因素和多因素分析。

结果

整个患者组的中位生存时间为33.3个月，1年、2年和3年总生存率分别为92.9%、75.4%和45.0%。单变量和多变量分析表明老年患者预后较好。

结论

患者年龄是接受放射治疗的弥漫性中线胶质瘤患者的独立预后因素。