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Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint
European Journal of Neroscience ( IF 3.4 ) Pub Date : 2024-02-20 , DOI: 10.1111/ejn.16279
Nicholas Pintori 1, 2 , Alessandro Piva 1 , Francesca Mottarlini 3 , Fernando Castillo Díaz 3 , Coralie Maggi 3 , Lucia Caffino 3 , Fabio Fumagalli 3 , Cristiano Chiamulera 1
Affiliation  

Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic mechanisms underlying appetitive memory and, in turn, modulate reward-seeking behaviours: here, we have investigated such a possibility following a brief EE exposure.

中文翻译:

短暂暴露于丰富的环境中可快速塑造大鼠大脑中的谷氨酸突触:化生指纹

环境浓缩(EE)已被证明对成瘾障碍产生有益的影响;然而,由于其配置的复杂性,其潜在机制尚未完全阐明。最近的证据表明,EE 作为化生剂,可能会影响食欲记忆的谷氨酸能机制,进而调节寻求奖励的行为:在这里,我们在短暂接触 EE 后研究了这种可能性。
更新日期:2024-02-20
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