Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross‐sectional study,Journal of Clinical Hypertension

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Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross‐sectional study
Journal of Clinical Hypertension ( IF 2.8 ) Pub Date : 2024-02-20 , DOI: 10.1111/jch.14766
Chuanli Yu _{1,

2,

3} , Congcong Ding _{1,

2,

3} , Lihua Hu ₄ , Yumeng Shi _{1,

2,

3} , Peixu Zhao _{1,

2,

3} , Jin´e Liu _{1,

2,

3} , Liting Zhang _{1,

2,

3} , Dan Sun _{1,

3} , Wei Zhou _{1,

2,

3} , Chao Yu _{2,

3,

5} , Tao Wang _{2,

3,

5} , Lingjuan Zhu _{2,

3,

5} , Xiao Huang _{1,

2,

3,

5} , Huihui Bao _{1,

2,

3,

5} , Xiaoshu Cheng _{1,

2,

3,

5}

Affiliation

Increased plasma homocysteine (Hcy) has been identified as one of the important risk factors for cardiovascular disease. However, the association between plasma Hcy and peripheral artery disease (PAD) is still controversial. This study aimed to investigate the association between plasma Hcy and PAD and the potential modifier factors in Chinese hypertensive adults. A total of 25 300 hypertensive patients aged 18 years or older were included in the analysis in this cross‐sectional study. The outcome was PAD, which defined as an ankle‐brachial index ≤0.90 in either limb. Multiple logistic regression was used to analyze the relationship between plasma Hcy and PAD. The median plasma Hcy was 14.00 (interquartile range: 11.60–17.80) μmol/L. There was a significant positive association between plasma Hcy and PAD (per SD increment; OR: 1.13; 95% CI: 1.06–1.19). Patients in the upper plasma Hcy tertile (≥16.16 μmol/L) were associated with a 53% increased risk of PAD compared with patients in the lower tertile (<12.33 μmol/L) after adjustment for multiple potential confounders. Subgroup analyses showed the association between Hcy and PAD was robust among various strata. Among Chinese adults with hypertension, plasma Hcy is an independent risk factor for PAD. This finding may improve the risk stratification of PAD.

更新日期：2024-02-20

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