Numerous studies support a bidirectional association between rheumatoid arthritis (RA), a chronic autoimmune degenerative inflammatory joint disease, and periodontitis, a chronic inflammatory disease caused by the immune reaction to bacteria organized in biofilms. RA and periodontitis are both multifactorial chronic inflammatory diseases that share common modifiable and non-modifiable risk factors. There is no cure for RA; treatment is based on lifestyle modifications and a variety of medications: nonsteroidal anti-inflammatory drugs (NSAID), glucocorticoids, and disease-modifying antirheumatic drugs (DMARDs, e.g., conventional synthetic DMARDs [csDMARDs]; biological DMARDs [bDMARD] and targeted synthetic DMARDs). There are molecular pathways of inflammation that are common to both RA and periodontitis. Thus, there is a potential effect of RA treatments on periodontitis. This systematic review aims to assess the impact of antirheumatic agents on periodontal conditions of patients suffering from both RA and periodontitis.

中文翻译：

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类风湿关节炎治疗对牙周病的影响：综述

许多研究支持类风湿性关节炎（RA）（一种慢性自身免疫性退行性炎症性关节病）和牙周炎（一种由对生物膜中组织的细菌的免疫反应引起的慢性炎症性疾病）之间的双向关联。RA和牙周炎都是多因素慢性炎症性疾病，具有共同的可改变和不可改变的危险因素。RA 无法治愈；治疗基于生活方式改变和各种药物：非甾体类抗炎药 (NSAID)、糖皮质激素和缓解病情抗风湿药（DMARD，例如传统合成 DMARD [csDMARD]；生物 DMARD [bDMARD] 和靶向合成 DMARD） ）。RA 和牙周炎都有一些共同的炎症分子途径。因此，RA 治疗对牙周炎有潜在的影响。本系统综述旨在评估抗风湿药物对患有 RA 和牙周炎的患者牙周状况的影响。