Co-loading of drugs/dyes onto nanoparticles is a widely adapted strategy to achieve synergistic/combinatorial effects. However, one of the co-loaded drugs may show dominant loading which reduces the loading efficiency of the other depending on the properties of the drug/dye loaded. Cisplatin (CDDP), a potent chemotherapeutic drug has very limited usage because of its poor aqueous solubility and systemic toxicity. A novel J-aggregate is formulated using indocyanine green (ICG) and CDDP called the ICG J-aggregate (IJA) which coordinates CDDP with ICG and enhances its water solubility resulting in higher loading. Further, polydopamine nanoparticles (PDA NPs) are used, which has shown excellent loading efficiency of IJA to form P-IJA nano formulation. The results for the first time provide evidence of 2–4 folds increase in CDDP's loading in IJA formulation in comparison to loading of free CDDP under the same conditions. The overall P-IJA formulation is capable of multi-modal cancer therapy, i.e., chemotherapy, photothermal therapy, photodynamic therapy, and ferroptosis-like selective cancer killing. The formulated P-IJA is also found to be biocompatible, hemocompatible, and stable. The finding of the study suggests that P-IJA can be effectively activated under NIR laser/pH as stimuli for deep-tissue synergistic therapy.

中文翻译：

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使用载有吲哚菁绿的聚多巴胺纳米颗粒的 J-聚集体的近红外响应药物混合物用于癌症化疗光疗

将药物/染料共同负载到纳米颗粒上是一种广泛采用的策略，以实现协同/组合效应。然而，一种共同负载的药物可能会显示出主导负载，这会降低另一种药物的负载效率，具体取决于负载的药物/染料的特性。顺铂（CDDP）是一种强效化疗药物，由于其水溶性差和全身毒性，其用途非常有限。一种新型 J-聚集体是使用吲哚菁绿 (ICG) 和 CDDP 配制而成，称为 ICG J-聚集体 (IJA)，它协调 CDDP 与 ICG 并增强其水溶性，从而产生更高的负载量。此外，使用聚多巴胺纳米颗粒（PDA NP），其显示出优异的IJA负载效率，形成P-IJA纳米制剂。结果首次提供了证据表明，与相同条件下游离 CDDP 的负载量相比，IJA 制剂中 CDDP 的负载量增加了 2-4 倍。整个P-IJA制剂能够进行多模式癌症治疗，即化疗、光热疗法、光动力疗法和类铁死亡样选择性杀癌。配制的 P-IJA 还具有生物相容性、血液相容性和稳定性。研究结果表明，P-IJA 在近红外激光/pH 刺激下可以有效激活，用于深层组织协同治疗。