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Is extended venous thromboprophylaxis required in patients undergoing ileal pouch procedure for ulcerative colitis?
Colorectal Disease ( IF 3.4 ) Pub Date : 2024-02-20 , DOI: 10.1111/codi.16912
Javier Gomez 1, 2 , Evangelia Theodosopoulos 1, 2 , Helen MacRae 1, 2 , Mantaj S. Brar 1, 2 , Anthony de Buck van Overstraeten 1, 2 , Brenda O'Connor 2 , Harden Huang 2 , Erin Kennedy 1, 2
Affiliation  

AimVenous thromboembolic events (VTEs) are relatively common adverse surgical complications. Extended VTE prophylaxis for 4 weeks is recommended after colorectal cancer surgery, but its use in inflammatory bowel disease surgery lacks high‐quality evidence. This retrospective study aimed to assess and characterize VTEs within the first 30 days after ileal pouch–anal anastomosis (IPAA) procedures and subtotal colectomies (STCs) for ulcerative colitis (UC).MethodsAll patients who underwent IPAA for UC between 1 January 2017 and 31 December 2021 were included. VTE rates after IPAA, in‐hospital or at‐home occurrences, utilization of in‐hospital thromboprophylaxis, and prescribed anticoagulant treatment were evaluated. Retrospectively, the same variables were analysed if patients of the cohort underwent STC before the IPAA construction.ResultsIn all, 204 patients underwent IPAA (61.8% men, 73% laparoscopic), with an average hospital stay of 6.8 days. Among them, 116 patients underwent STC prior to IPAA. Thirteen patients (6.3%) experienced VTEs after IPAA, with 76.9% (10/13) of cases occurring during hospitalization and under adequate thromboprophylaxis. The VTE rate after STC was 10.3% (12/116), with 58.2% (7/12) occurring in hospital and under appropriate thromboprophylaxis. No reoperations or mortality were attributed to thrombotic events. The type and duration of anticoagulant treatment varied considerably.ConclusionThe VTE rate after IPAA for UC was 6.3%, with the majority of events occurring in hospital and under adequate thromboprophylaxis. These findings suggest that routine use of extended VTE prophylaxis in our cohort may not be supported. Further research is needed to clarify the optimal VTE prophylaxis strategy for inflammatory bowel disease surgery.

中文翻译:

接受回肠储袋手术治疗溃疡性结肠炎的患者是否需要延长静脉血栓预防?

目的静脉血栓栓塞事件(VTE)是相对常见的手术不良并发症。建议结直肠癌手术后延长 4 周的 VTE 预防,但其在炎症性肠病手术中的应用缺乏高质量的证据。这项回顾性研究旨在评估和描述溃疡性结肠炎 (UC) 回肠袋-肛门吻合术 (IPAA) 手术和结肠次全切除术 (STC) 后前 30 天内的 VTE。 方法 2017 年 1 月 1 日至 31 日期间接受 IPAA 治疗 UC 的所有患者2021 年 12 月也包括在内。对 IPAA 后的 VTE 发生率、院内或家中发生情况、院内血栓预防的使用情况以及处方抗凝治疗进行了评估。回顾性地,如果队列患者在 IPAA 构建之前接受 STC,则对相同的变量进行分析。结果 总共 204 名患者接受了 IPAA(61.8% 男性,73% 腹腔镜),平均住院时间为 6.8 天。其中,116 名患者在 IPAA 之前接受了 STC。13 名患者 (6.3%) 在 IPAA 后经历了 VTE,其中 76.9% (10/13) 的病例发生在住院期间且接受充分的血栓预防。STC 后的 VTE 发生率为 10.3% (12/116),其中 58.2% (7/12) 发生在医院并接受适当的血栓预防。没有因血栓事件导致再次手术或死亡。抗凝治疗的类型和持续时间差异很大。结论 UC 进行 IPAA 后的 VTE 发生率为 6.3%,其中大多数事件发生在医院内且进行了充分的血栓预防。这些发现表明,在我们的队列中常规使用延长 VTE 预防可能不受支持。需要进一步研究来阐明炎症性肠病手术的最佳 VTE 预防策略。
更新日期:2024-02-20
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