Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Comprehensive analysis of environmental exposure to hazardous trace elements and lung function: a national cross-sectional study
Thorax ( IF 10 ) Pub Date : 2024-02-22 , DOI: 10.1136/thorax-2022-219839 Yun-Jiang Yu , Tong Zheng , Jennifer L Perret , Yajing Han , Hongyan Li , Wenjie Meng , Dinh Bui , Qi-Zhen Wu , Chenyin Dong , Qiu-Ling Fang , Zhenchi Li , Hongxuan Kuang , Xiaowen Chen , Mingdeng Xiang , Xiaodi Qin , Shyamali C Dharmage , Guang-Hui Dong , Yang Zhou
Thorax ( IF 10 ) Pub Date : 2024-02-22 , DOI: 10.1136/thorax-2022-219839 Yun-Jiang Yu , Tong Zheng , Jennifer L Perret , Yajing Han , Hongyan Li , Wenjie Meng , Dinh Bui , Qi-Zhen Wu , Chenyin Dong , Qiu-Ling Fang , Zhenchi Li , Hongxuan Kuang , Xiaowen Chen , Mingdeng Xiang , Xiaodi Qin , Shyamali C Dharmage , Guang-Hui Dong , Yang Zhou
Background There is growing interest in the joint effects of hazardous trace elements (HTEs) on lung function deficits, but the data are limited. This is a critical research gap given increased global industrialisation. Methods A national cross-sectional study including spirometry was performed among 2112 adults across 11 provinces in China between 2020 and 2021. A total of 27 HTEs were quantified from urine samples. Generalised linear models and quantile-based g-computation were used to explore the individual and joint effects of urinary HTEs on lung function, respectively. Results Overall, there were negative associations between forced expiratory volume in 1 s (FEV1) and urinary arsenic (As) (z-score coefficient, −0.150; 95% CI, −0.262 to –0.038 per 1 ln-unit increase), barium (Ba) (−0.148, 95% CI: −0.258 to –0.039), cadmium (Cd) (−0.132, 95% CI: −0.236 to –0.028), thallium (Tl) (−0.137, 95% CI: −0.257 to –0.018), strontium (Sr) (−0.147, 95% CI: −0.273 to –0.022) and lead (Pb) (−0.121, 95% CI: −0.219 to –0.023). Similar results were observed for forced vital capacity (FVC) with urinary As, Ba and Pb and FEV1/FVC with titanium (Ti), As, Sr, Cd, Tl and Pb. We found borderline associations between the ln-quartile of joint HTEs and decreased FEV1 (−20 mL, 95% CI: −48 to +8) and FVC (−14 mL, 95% CI: −49 to+2). Ba and Ti were assigned the largest negative weights for FEV1 and FVC within the model, respectively. Conclusion Our study investigating a wide range of HTEs in a highly polluted setting suggests that higher urinary HTE concentrations are associated with lower lung function, especially for emerging Ti and Ba, which need to be monitored or regulated to improve lung health. Data are available upon reasonable request.
更新日期：2024-02-23
京公网安备 11010802027423号