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Allografts use in orthopedic surgery: trend change over the past 11 years from a regional tissue bank
Cell and Tissue Banking ( IF 1.5 ) Pub Date : 2024-02-22 , DOI: 10.1007/s10561-024-10134-3
Andrea Della Valle , Riccardo Compagnoni , Francesco Puglia , Daniele Priano , Alessandra Menon , Lorenzo Teani , Giovanni Andrea La Maida , Tullia De Feo , Marco Sacchi , Federico Ambrogi , Alfonso Cicatelli , Pietro Simone Randelli

Allografts are the second most transplanted tissue in medicine after blood and are now increasingly used for both primary and revision surgery. Allografts have the advantages of lower donor site morbidity, availability of multiple grafts, and shorter operative time. The Banks represents the bridge between Donor and Recipient and guarantees the quality and safety of the distributed allografts Given the increasing interest in these tissues, a retrospective analysis of data collected from the Regional Musculoskeletal Tissue Bank registry over an 11-year period (2009–2019) was conducted. The statistical analyses used were the Shapiro–Wilk normality test and a Poisson regression model. From January 2009 to December 2019, a total of 14,199 musculoskeletal tissues stored in the Regional Musculoskeletal Tissue Bank were provided for surgical allograft procedures. In 2009, the number of allografts performed was 925; this figure has steadily increased to 1599 in 2019. Epiphyses were taken as the reference tissue with an almost constant trend over the period, while a significant increase was denoted for extensor mechanism allograft, ligaments, tendons and long bone corticals (p < 0.001), processed bone tissues had no change in trend (p = 0.841). There was also a gradual decrease in the rate of microbiological positivity, as determined by bacteriological and serological tests performed on the collected tissues. This phenomenon is due to improved sampling techniques and the training of a dedicated team. Thus, we have seen how the use of allografts in orthopedic surgery has increased over the past 11 years, uniformly in terms of tissue type, except for the noticeable increase in ligamentous tissue.



中文翻译:

同种异体移植物在骨科手术中的使用:区域组织库过去 11 年的趋势变化

同种异体移植是医学上仅次于血液的第二大移植组织,现在越来越多地用于初次手术和翻修手术。同种异体移植具有供体部位发病率较低、可提供多个移植物以及手术时间较短的优点。该银行代表了捐赠者和接受者之间的桥梁,保证了分布式同种异体移植物的质量和安全性鉴于人们对这些组织的兴趣日益浓厚,对 11 年期间(2009-2019 年)从区域肌肉骨骼组织银行登记处收集的数据进行了回顾性分析)进行了。使用的统计分析是夏皮罗-威尔克正态性检验和泊松回归模型。从2009年1月到2019年12月,区域肌肉骨骼组织库中储存的总共14,199个肌肉骨骼组织被提供用于外科同种异体移植手术。2009年,同种异体移植手术数量为925例;这一数字在 2019 年稳步增加至 1599 个。以骨骺作为参考组织,在此期间几乎保持不变的趋势,而伸肌机制同种异体移植物、韧带、肌腱和长骨皮质则显着增加 (p < 0.001),处理过的骨组织没有趋势变化(p = 0.841)。根据对收集的组织进行的细菌学和血清学测试确定,微生物学阳性率也逐渐下降。这种现象归因于采样技术的改进和专门团队的培训。因此,我们已经看到过去 11 年中同种异体移植物在骨科手术中的使用如何增加,除了韧带组织明显增加之外,在组织类型方面是一致的。

更新日期:2024-02-23
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