In this study, 16 new compounds, six bibenzyls (–) and 10 naphthalenes (–), including three pairs of naphthalene enantiomers and three known compounds (), were isolated from Structurally, compounds are previously undescribed dimeric bibenzyls, uniquely linked by unusual carbon bonds. The structures of the compounds were determined using spectroscopy and X-ray crystallography. The screening results indicated that , , and showed remarkable lipid-lowering activities in FFA-induced HepG2 cells, with EC values ranging from 3.13 to 6.57 μM. Moreover, , , and significantly decreased both the mRNA and protein levels of the target SREBP-1c, and also reduced PPARα mRNA and protein levels. Therefore, , , and are potential drugs against hepatic steatosis by targeting PPAR or SREBP-1c.

中文翻译：

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菊花石斛的联苄基和萘衍生物及其抗肝脂肪变性活性

在这项研究中，从结构上分离出 16 种新化合物，即 6 种联苄 (–) 和 10 种萘 (–)，其中包括三对萘对映体和 3 种已知化合物 ()。债券。使用光谱学和X射线晶体学确定了化合物的结构。筛选结果表明，、、、对FFA诱导的HepG2细胞具有显着的降脂活性，EC值范围为3.13~6.57μM。此外， 、 、 和 显着降低了靶标 SREBP-1c 的 mRNA 和蛋白质水平，并且还降低了 PPARα mRNA 和蛋白质水平。因此，、、、和是靶向PPAR或SREBP-1c的抗肝脂肪变性的潜在药物。