Influenced by the global aging population, the incidence of Alzheimer's disease (AD) has increased sharply. In addition to increasing β-amyloid plaque deposition and tau tangle formation, neurogenesis dysfunction has recently been observed in AD. Therefore, promoting regeneration to improve neurogenesis and cognitive dysfunction can play an effective role in AD treatment. Acupuncture and moxibustion have been widely used in the clinical treatment of neurodegenerative diseases because of their outstanding advantages such as early, functional, and benign two-way adjustment. It is urgent to clarify the effectiveness, greenness, and safety of acupuncture and moxibustion in promoting neurogenesis in AD treatment. Senescence-accelerated mouse prone 8 (SAMP8) mice at various ages were used as experimental models to simulate the pathology and behaviors of AD mice. Behavioral experiments, immunohistochemistry, Western blot, and immunofluorescence experiments were used for comparison between different groups. Acupuncture and moxibustion could increase the number of PCNA DCX cells, Nissl bodies, and mature neurons in the hippocampal Dentate gyrus (DG) of SAMP8 mice, restore the hippocampal neurogenesis, delay the AD-related pathological presentation, and improve the learning and memory abilities of SAMP8 mice. The pathological process underlying AD and cognitive impairment were changed positively by improving the dysfunction of neurogenesis. This indicates the promising role of acupuncture and moxibustion in the prevention and treatment of AD.

中文翻译：

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SAMP8小鼠海马齿状回神经发生的变化及针灸的影响

受全球人口老龄化影响，阿尔茨海默病（AD）发病率急剧上升。除了β-淀粉样斑块沉积和tau缠结形成增加之外，最近在AD中还观察到神经发生功能障碍。因此，促进再生改善神经发生和认知功能障碍可以在AD治疗中发挥有效作用。针灸以其早期、功能性、良性双向调节等突出优势，在神经退行性疾病的临床治疗中得到广泛应用。阐明针灸促进神经发生治疗AD的有效性、绿色性和安全性刻不容缓。以不同年龄的衰老加速小鼠倾向8（SAMP8）小鼠为实验模型，模拟AD小鼠的病理和行为。采用行为实验、免疫组化、Western blot、免疫荧光实验进行不同组间比较。针灸可增加SAMP8小鼠海马齿状回（DG）PCNA DCX细胞、尼氏小体和成熟神经元的数量，恢复海马神经发生，延缓AD相关病理表现，提高学习记忆能力SAMP8 小鼠。通过改善神经发生功能障碍，可以积极改变AD和认知障碍的病理过程。这表明针灸在预防和治疗AD方面具有广阔的前景。