The ischemia–reperfusion (I/R) injury seen in the heart can cause severe damage to essential organs such as the brain. Cannabidiol (CBD) obtained from Cannabis sativa is used today to treat various diseases. This study aimed to demonstrate CBD's neuroprotective and therapeutic properties in rats with brain damage caused by I/R in the heart. Rats were divided into four groups; sham, I/R, I/R + Prophylactic CBD, and I/R + Therapeutic CBD. End of the experiment, brain tissues were collected for biochemical, histopathological, and genetic examinations. I/R damage increased the number of degenerative neurons, caspase-3 and TNF-α immunoexpression, total oxidant status levels, and oxidative stress index. Both prophylactic and therapeutic CBD administration reduced these increased values. In addition, the relative fold changes of AMPK, PGC-1α, SIRT1, and Bcl 2 decreased in the I/R group, and the relative fold change of Bax increased, which are indicators of ER stress and apoptosis. Both administrations of CBD reversed these genes' relative fold changes. CBD can be protective against brain injury caused by cardiac I/R damage through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.

中文翻译：

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大麻二酚在急性冠状动脉综合征模型中的神经保护和治疗作用研究

心脏的缺血再灌注（I/R）损伤会对大脑等重要器官造成严重损害。从大麻中提取的大麻二酚 (CBD) 如今用于治疗各种疾病。这项研究旨在证明 CBD 对因心脏缺血再灌注引起的脑损伤的大鼠的神经保护和治疗特性。将大鼠分为四组；假手术、I/R、I/R + 预防性 CBD 和 I/R + 治疗性 CBD。实验结束时，收集脑组织进行生化、组织病理学和遗传学检查。I/R损伤增加了退行性神经元的数量、caspase-3和TNF-α免疫表达、总氧化状态水平和氧化应激指数。预防性和治疗性 CBD 给药均减少了这些增加的值。此外，I/R组中AMPK、PGC-1α、SIRT1和Bcl 2的相对倍数变化减少，Bax的相对倍数变化增加，这些都是ER应激和细胞凋亡的指标。CBD 的两次给药都逆转了这些基因的相对倍数变化。CBD 可以通过抗氧化、抗炎和抗凋亡机制来保护心脏 I/R 损伤引起的脑损伤。