BackgroundThe aim of our study was to evaluate real-world implementation of Slovenia’s national HIV PrEP programme, which is fully covered by our national health insurance.MethodsIn retrospective cohort study we analysed the data from all men who have sex with men (MSM) who were enrolled in PrEP programme of our clinic between 1 January 2022 and 31 December 2022.ResultsA total of 190 MSM with an average age of 36.7 years were included in our analysis. 151 (79.5%) decided for event-driven PrEP and 39 (20.5%) opted for daily PrEP. Self-reported adherence was 95%. Among eligibility criteria, unprotected sex was the most common one, followed by one or more STIs in the past, use of chemsex and use of HIV post-exposure prophylaxis in the past. No new cases of HIV infection and no significant deterioration of kidney or liver function were observed during the follow-up. Sixty-seven episodes of STIs were diagnosed and treated. Gonorrhea (32), chlamydia (14), and Mpox (10) were the most common ones.ConclusionsPrEP was successfully implemented into everyday clinical practice, proving to be both safe and effective. High number of diagnosed STIs suggests that the PrEP programme, combined with STI screening and vaccination, provides a strong public health impact among MSM in Slovenia.

中文翻译：

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斯洛文尼亚国家 HIV PrEP 计划：对现实世界实施情况的评估

背景我们研究的目的是评估斯洛文尼亚国家 HIV PrEP 计划的实际实施情况，该计划完全由我们的国家健康保险承保。方法在回顾性队列研究中，我们分析了所有男男性行为者 (MSM) 的数据，这些男性是于2022年1月1日至2022年12月31日期间参加我们诊所的PrEP项目。结果我们的分析共纳入了190名MSM，平均年龄为36.7岁。151 人 (79.5%) 决定进行事件驱动的 PrEP，39 人 (20.5%) 选择每日 PrEP。自我报告的依从率为 95%。在资格标准中，无保护性行为是最常见的一种，其次是过去曾患过一种或多种性传播感染、使用化学性行为以及过去使用过艾滋病毒暴露后预防。随访期间未发现新的艾滋病毒感染病例，肾功能或肝功能未出现明显恶化。诊断并治疗了 67 例性传播感染。淋病 (32)、衣原体 (14) 和 Mpox (10) 是最常见的。结论 PrEP 已成功应用于日常临床实践，证明是安全有效的。大量确诊的性传播感染表明，PrEP 计划与性传播感染筛查和疫苗接种相结合，对斯洛文尼亚 MSM 的公共卫生产生了强大的影响。