Celiac disease (CeD) and eosinophilic esophagitis (EoE) are immune-mediated disorders that can occur in the same patient. A retrospective study at a tertiary care hospital was conducted to determine the prevalence of EoE in a pediatric population with CeD and to compare characteristics of patients with both diseases to patients with CeD-only. Among the 148 patients with CeD identified in the study, 11 patients had both CeD and EoE (7.4%). Patients with both CeD and EoE had a higher absolute eosinophil count (per μL) at diagnosis compared to patients with CeD-only (454.1 ± 122.7 vs 231.9 ± 19.4, P = .003). In conclusion, there was a higher proportion of EoE in patients with CeD than would be expected in the general population, suggesting a potential pathophysiological overlap between the 2 diseases. An elevated peripheral absolute eosinophil count may help predict which patients with CeD may additionally have EoE.

中文翻译：

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儿童群体中并发乳糜泻和嗜酸性食管炎：不仅仅是巧合

乳糜泻 (CeD) 和嗜酸性粒细胞性食管炎 (EoE) 是免疫介导的疾病，可能发生在同一患者身上。在一家三级医院进行了一项回顾性研究，以确定患有 CeD 的儿科人群中 EoE 的患病率，并比较患有这两种疾病的患者与仅患有 CeD 的患者的特征。在研究中确定的 148 名 CeD 患者中，11 名患者同时患有 CeD 和 EoE（7.4%）。与仅患有 CeD 的患者相比，同时患有 CeD 和 EoE 的患者在诊断时具有更高的绝对嗜酸性粒细胞计数（每 μL）（454.1 ± 122.7 vs 231.9 ± 19.4，P = .003）。总之，CeD 患者中 EoE 的比例高于一般人群的预期，表明这两种疾病之间存在潜在的病理生理学重叠。外周血绝对嗜酸性粒细胞计数升高可能有助于预测哪些 CeD 患者可能还患有 EoE。