Infective endocarditis (IE) is common in patients with liver disease. Outcomes of IE in patients with liver disease are limited. We aimed to investigate IE outcomes in patients with variables associated with liver disease in the USA. We used the 2017 National Readmission Database to identify index admission of adults with IE, based on the International Classification of Disease, 10th revision codes. The primary outcome was 30-day readmission. Secondary outcomes were mortality and predictors of hospital readmission. We identified 40,413 IE admissions. Patients who were readmitted were more likely to have a history of HCV (19.4 vs 12.3%, P < .001), hyponatremia (25 vs 21%, P < .001), and thrombocytopenia (20.3 vs 16.3%, P < .001). After adjusting for age, hypertension, heart failure, diabetes mellitus, and end stage renal disease, hyponatremia (odds ratio (OR) 1.25; 95% confidence intervals [CI]: 1.17–1.35; P < .001) and thrombocytopenia (OR 1.16; 95% CI: 1.08–1.24; P < .001) correlated with higher odds of 30-day readmission. Mortality was higher among patients with hyponatremia (29 vs 22%, P < .001), thrombocytopenia (29 vs 17%, P < .001), coagulopathy (12 vs 5%, P < .001), cirrhosis (6 vs 4%, P < .001), ascites (7 vs 3%, P < .001), liver failure (18 vs 3%, P < .001), and portal hypertension (3 vs 1.5%, P < .001).

中文翻译：

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美国患有肝病相关变量的患者感染性心内膜炎再入院的患病率、特征和结果

感染性心内膜炎（IE）在肝病患者中很常见。肝病患者 IE 的结果有限。我们的目的是调查美国患有肝病相关变量的患者的 IE 结果。我们使用 2017 年国家再入院数据库根据国际疾病分类 10 确定 IE 成人入院指数th修订代码。主要结果是 30 天再入院。次要结局是死亡率和再入院的预测因素。我们确定了 40,413 名 IE 录取学生。再入院的患者更有可能有 HCV 病史（19.4 vs 12.3%，P < .001）、低钠血症病史（25 vs 21%，P < .001）和血小板减少症病史（20.3 vs 16.3%，P < .001） ）。调整年龄、高血压、心力衰竭、糖尿病和终末期肾病、低钠血症（比值比 (OR) 1.25；95% 置信区间 [CI]：1.17–1.35；P < .001）和血小板减少症 (OR 1.16) 后；95% CI：1.08–1.24；P < .001）与 30 天再入院的较高几率相关。低钠血症 (29 vs 22%，P < .001)、血小板减少症 (29 vs 17%，P < .001)、凝血功能障碍 (12 vs 5%，P < .001)、肝硬化 (6 vs 4) 患者的死亡率较高%，P < .001）、腹水（7 vs 3%，P < .001）、肝衰竭（18 vs 3%，P < .001）和门静脉高压（​​3 vs 1.5%，P < .001）。