Aortic aneurysm (AA) is a serious disease that affects the aging population worldwide. Potential risk or associated factors, such as inguinal hernia, have been suggested by conventional studies. In the present study, summary statistics data for the associations of inguinal hernia were derived from a large genome-wide association study including 18,791 inguinal hernia cases and 93,955 controls in the UK Biobank. Corresponding data of AA were extracted from FinnGen, comprising 7603 cases and 317,899 controls in Finland. The causal association was assessed using Mendelian Randomization-Egger, weighted median, and inverse variance weighting methods, and compared with observational estimates previously published. Our analysis found no convincing causal effect between genetically predicted inguinal hernia and the risk of AA (odds ratio [OR] = 1.05, 95% confidence interval [CI] = 0.85–1.31, P = .65), abdominal aortic aneurysm (AAA, OR = 1.15, 95% CI = 0.92-1.46, P = .22), and thoracic aortic aneurysm (TAA, OR = 1.05, 95% CI = 0.85–1.30, P = .67). The results are in contrast to previous observational evidence suggesting a potentially common causal association between inguinal hernia and AA. Further research is needed to better understand the interplay between risk factors and their impact on aneurysm development.

中文翻译：

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使用孟德尔随机分析发现腹股沟疝与主动脉瘤之间没有因果关系

主动脉瘤（AA）是一种影响全球老龄化人口的严重疾病。传统研究已提示存在潜在风险或相关因素，例如腹股沟疝。在本研究中，腹股沟疝关联性的汇总统计数据来自一项大型全基因组关联研究，包括英国生物银行的 18,791 例腹股沟疝病例和 93,955 例对照。AA 的相应数据来自 FinnGen，包括芬兰的 7603 例病例和 317,899 例对照。使用孟德尔随机化-Egger、加权中位数和逆方差加权方法评估因果关系，并与之前发表的观察估计值进行比较。我们的分析发现，基因预测的腹股沟疝与 AA 风险之间没有令人信服的因果关系（比值比 [OR] = 1.05，95% 置信区间 [CI] = 0.85–1.31，P = 0.65）、腹主动脉瘤 (AAA、 OR = 1.15，95% CI = 0.92-1.46，P = .22）和胸主动脉瘤（TAA，OR = 1.05，95% CI = 0.85-1.30，P = .67）。该结果与之前的观察证据形成鲜明对比，之前的观察证据表明腹股沟疝和 AA 之间存在潜在的常见因果关系。需要进一步的研究来更好地了解风险因素之间的相互作用及其对动脉瘤发展的影响。