Several epidemiological studies suggested that frequency of tooth brushing may be associated with cardiovascular disease (CVD) risk, but the results remain inconclusive. Therefore, the aim of this study was to synthesize frequency of tooth brushing and CVD risk using meta-analysis. Science Direct, PubMed, CINAHL, and OVID were searched through October 15, 2022. The random-effects model was used to quantitatively assess the combined risk estimation. In addition, we performed the sensitivity analysis to evaluate the robustness of the study results by excluding the included studies one by one. A total of 9 cohort studies containing 10 reports with 803,019 individuals were included in the meta-analysis. Pooled results showed that compared with the lowest brushing frequency, the highest brushing frequency (relative risk = 0.85, 95% confidence interval: 0.80–0.90) significantly reduced the risk of cardiovascular disease. There was moderate heterogeneity among included studies ( P = .002, I2 = 65.4%). The exclusion of any one study did not materially change the combined risk estimates. Our meta-analysis supported the hypothesis that higher frequency of tooth brushing can reduce the risk of CVD, which may have important implications for conducting research on the prevention strategies of CVD.

中文翻译：

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刷牙频率与心血管疾病风险之间的关联：系统评价和荟萃分析

多项流行病学研究表明，刷牙频率可能与心血管疾病（CVD）风险相关，但结果仍无定论。因此，本研究的目的是通过荟萃分析来综合刷牙频率和 CVD 风险。Science Direct、PubMed、CINAHL 和 OVID 的检索截止日期为 2022 年 10 月 15 日。随机效应模型用于定量评估组合风险估计。此外，我们通过一一排除纳入的研究，进行敏感性分析，以评估研究结果的稳健性。荟萃分析共纳入 9 项队列研究，包含 10 份报告，涉及 803,019 名受试者。汇总结果显示，与最低刷牙频率相比，最高刷牙频率（相对风险 = 0.85，95% 置信区间：0.80–0.90）显着降低了心血管疾病的风险。纳入的研究之间存在中等异质性 ( P = .002，I2= 65.4%）。排除任何一项研究并没有实质性改变综合风险估计。我们的荟萃分析支持了这样的假设，即较高的刷牙频率可以降低 CVD 的风险，这可能对开展 CVD 预防策略的研究具有重要意义。