PurposeTo evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR).Methods120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were measured at baseline and after 3 months intervention.ResultsComparison among groups showed that fasting plasma glucose (FPG), 2 h post glucose (2hPPG), fasting insulin (FINS) and homeostatic model assessment for insulin resistance (HOMA-IR) in Cr + Mg group were significantly decreased compared with the other three groups ( p < .05), and high density lipoprotein (HDL-c) levels were higher. 8-iso prostaglandin F2 alpha (8-iso-PGF2a) decreased in Cr, Mg, and Cr + Mg groups compared with placebo ( p < .05), and 8-iso-PGF2a decreased in Cr + Mg groups compared with Cr group and Mg groups ( p > .05). Intra-group comparison showed that the levels of FPG, 2hPPG and FINS in Cr + Mg group were significantly decreased after intervention ( p < .05), and FINS in Mg group was significantly decreased ( p < .01). The levels of HDL-c and triacylglycerol (TG) in Cr + Mg group were significantly improved ( p < .05). The level of HDL-c in Mg group was significantly improved compared with baseline ( p < .05). Compared with baseline, high-sensitivity C-reactive protein (hsCRP) levels in Cr + Mg group and Mg group were significantly decreased ( p < .05).ConclusionsThe co-supplementation of Cr and Mg improves glycemic and lipid levels and reduces the inflammatory response and oxidative stress profiles of individuals with impaired glucose tolerance and insulin resistance.

中文翻译：

---

铬和镁联合补充对糖耐量受损的代谢特征、炎症和氧化应激的影响

目的评估铬 (Cr) 和镁 (Mg) 离子对糖耐量受损 (IGT) 和胰岛素抵抗 (IR) 代谢特征、炎症和氧化应激的影响。方法将 120 名患有 IGT 和 IR 的个体随机分为四组用 (1) 铬、(2) 镁、(3) 铬和镁或 (4) 安慰剂治疗。在基线和干预3个月后测量代谢和炎症指标。结果组间比较显示空腹血糖（FPG）、血糖后2小时（2hPPG）、空腹胰岛素（FINS）和胰岛素抵抗稳态模型评估（HOMA-IR） Cr + Mg 组的 ) 与其他三组相比显着降低 ( p < .05)，且高密度脂蛋白 (HDL-c) 水平较高。与安慰剂相比，Cr、Mg 和 Cr + Mg 组中 8-iso 前列腺素 F2 α (8-iso-PGF2a) 降低 ( p < .05)，与 Cr 组相比，Cr + Mg 组中 8-iso-PGF2a 降低和 Mg 组 ( p > .05)。组内比较显示，Cr+Mg组干预后FPG、2hPPG和FINS水平均显着降低（p<.05），Mg组FINS显着降低（p<.01）。Cr + Mg 组的 HDL-c 和三酰甘油 (TG) 水平显着提高 ( p < .05)。与基线相比，镁组 HDL-c 水平显着改善 (p < .05)。与基线相比，Cr + Mg 组和 Mg 组的高敏 C 反应蛋白 (hsCRP) 水平显着降低 ( p < .05)。结论 Cr 和 Mg 联合补充可改善血糖和血脂水平，并减少炎症糖耐量受损和胰岛素抵抗个体的反应和氧化应激谱。