The prognostic value of bone mineral content (BMC) for the clinical outcomes of patients with coronary artery disease (CAD) remains unknown. The present study evaluated the association between BMC index (BMCI) and cardiovascular events between January 2020 to June 2021, in consecutive patients (n = 257) with CAD undergoing percutaneous coronary intervention (PCI) at the Nagano Municipal Hospital. BMCI was measured using bioelectrical impedance analysis and calculated as the BMC divided by height squared. Patients were classified as low (<0.918) or high BMCI (≥0.918) groups according to the receiver operating characteristics curve analysis for the primary endpoint, major adverse cardiovascular events (MACE), including cardiovascular death, spontaneous myocardial infarction, stroke, and any revascularization. During a median follow-up of 744 days, the low BMCI group (n = 152) had an increased risk of MACE compared with the high group (n = 105) (19.7 vs 6.7%, P = .004). A low BMCI was significantly associated with MACE in the multivariable Cox and the Inverse Probability of Treatment Weighting analyses (hazard ratio: 3.16, 95% confidence interval: 1.15-8.67, P = .025). In conclusion, among patients with CAD undergoing PCI, BMCI was a predictor for cardiovascular events. Further research is required to determine whether medical interventions for BMC can improve patient prognosis.

中文翻译：

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低骨矿物质含量指数对接受经皮冠状动脉介入治疗的冠心病患者心血管结局的影响

骨矿物质含量 (BMC) 对冠状动脉疾病 (CAD) 患者临床结果的预后价值仍不清楚。本研究评估了 2020 年 1 月至 2021 年 6 月期间在长野市立医院接受经皮冠状动脉介入治疗 (PCI) 的连续 CAD 患者 (n = 257) 之间的 BMC 指数 (BMCI) 与心血管事件之间的关联。BMCI 使用生物电阻抗分析进行测量，并计算为 BMC 除以身高的平方。根据主要终点、主要不良心血管事件 (MACE) 的受试者工作特征曲线分析，将患者分为低 BMCI (<0.918) 或高 BMCI (≥0.918) 组，包括心血管死亡、自发性心肌梗死、卒中和任何其他事件。血运重建。在中位随访 744 天期间，低 BMCI 组 (n = 152) 与高组 (n = 105) 相比，MACE 风险增加 (19.7% vs 6.7%，P = .004)。在多变量 Cox 和治疗加权逆概率分析中，低 BMCI 与 MACE 显着相关（风险比：3.16，95% 置信区间：1.15-8.67，P = .025）。总之，在接受 PCI 的 CAD 患者中，BMCI 是心血管事件的预测因子。需要进一步的研究来确定 BMC 的医疗干预是否可以改善患者的预后。