We studied the impact of estimated glomerular filtration rate (eGFR) based on either creatinine or cystatin C, or in combination, on vascular aging (aortic stiffness) and central hemodynamics (central systolic blood pressure) in a Swedish urban population with median 17 years of follow-up. Participants ( n = 5049) from the population-based Malmö Diet and Cancer Study that underwent baseline examination and later participated in the prospective cardiovascular arm were selected. Of these, 2064 with measured carotid-femoral pulse wave velocity (cfPWV) and central blood pressure at follow-up were enrolled. eGFR was calculated using cystatin C (eGFRCYS) and creatinine (eGFRCR) equations: Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised (LMrev), and the European Kidney Function Consortium (EKFC) equations. Lower adjusted eGFRCR, but not eGFRCYS, were independently associated with higher cfPWV ( P < .001, respectively). eGFR <60 mL/min/1.73 m2 determined higher cfPWV except when using the EKFC equation. Conversely, CAPA/LMrev and CAPA/EKFC ratios were not associated with aortic stiffness. Lower eGFRCR is associated with higher future aortic stiffness independently of age, sex, heart rate, mean blood pressure, body mass index, and antihypertensive treatment. The ratio of eGFRCYS and eGFRCR equations could not predict aortic stiffness at all.

中文翻译：

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马尔默饮食癌症研究中长期随访的不同 eGFR 公式可预测主动脉僵硬度

我们研究了基于肌酐或胱抑素 C 或两者联合估计的肾小球滤过率 (eGFR) 对瑞典城市人口血管老化（主动脉僵硬度）和中心血流动力学（中心收缩压）的影响，该人群中位年龄为 17 年。跟进。选择来自基于人群的马尔默饮食和癌症研究的参与者（n = 5049），他们接受了基线检查，后来参加了前瞻性心血管组。其中，2064 名患者在随访时测量了颈动脉-股动脉脉搏波速度 (cfPWV) 和中心血压。eGFR 使用胱抑素 C 计算（eGFRCYS) 和肌酐 (eGFRCR) 方程：高加索人、亚洲人、儿童和成人队列 (CAPA)、Lund-Malmö 修订版 (LMrev) 和欧洲肾功能联盟 (EKFC) 方程。降低调整后的 eGFRCR，但不是 eGFRCYS，与较高的 cfPWV 独立相关（分别为 P < .001）。eGFR <60 mL/min/1.73 m2确定较高的 cfPWV，除非使用 EKFC 方程。相反，CAPA/LMrev 和 CAPA/EKFC 比值与主动脉僵硬度无关。降低肾小球滤过率CR与未来较高的主动脉僵硬度相关，与年龄、性别、心率、平均血压、体重指数和抗高血压治疗无关。eGFR 比率CYS和肾小球滤过率CR方程根本无法预测主动脉僵硬度。