The microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients with DLBCL were included in the analysis. This meta-analysis confirmed that high densities of Foxp3+Tregs and PD-1+T cells are good indicators for overall survival (OS) in DLBCL, while high densities of programmed cell death protein ligand1(PD-L1)-positive expression cells and T-cell immunoglobulin-and mucin domain-3-containing molecule 3 (TIM-3)-positive expression tumor-infiltrating cells (TILs) play a contrary role in OS. Additionally, higher numbers of T-cell intracytoplasmic antigen-1(TIA-1)-positive expression T cells imply better OS and progression-free survival (PFS), while high numbers of lymphocyte activation gene(LAG)-positive expression TILs predict bad OS and PFS. Various non-tumoral cells in the microenvironment play important roles in the prognosis of DLBCL.

中文翻译：

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非肿瘤细胞作为弥漫性大 B 细胞淋巴瘤的预后生物标志物：系统回顾和荟萃分析

弥漫性大B细胞淋巴瘤（DLBCL）的微环境由多种成分组成，包括免疫细胞和免疫检查点，其中一些成分与DLBCL的预后相关，但其结果仍存在争议。因此，我们进行了系统回顾和荟萃分析，以探讨 DLBCL 微环境与预后之间的关联。我们检索了 PubMed、Web of Science 和 EMBASE 2001 年至 2022 年间的相关文章。分析中纳入了涉及 4495 名 DLBCL 患者的 25 项研究。这项荟萃分析证实，高密度的 Foxp3+Treg 和 PD-1+T 细胞是 DLBCL 总体生存 (OS) 的良好指标，而高密度的程序性细胞死亡蛋白配体 1 (PD-L1) 阳性表达细胞和T 细胞免疫球蛋白和含有粘蛋白结构域 3 的分子 3 (TIM-3) 阳性表达的肿瘤浸润细胞 (TIL) 在 OS 中发挥相反的作用。此外，较高数量的 T 细胞胞浆内抗原 1 (TIA-1) 阳性表达 T 细胞意味着更好的 OS 和无进展生存 (PFS)，而大量淋巴细胞激活基因 (LAG) 阳性表达 TIL 则预示着不良情况操作系统和 PFS。微环境中的各种非肿瘤细胞在DLBCL的预后中发挥着重要作用。