Objective:To examine the effects of triple beaded mixed amphetamine salts (TB MAS) on ADHD and executive dysfunction symptoms throughout the day in adults with DSM-5 ADHD.Method:This was a 6 week, single-blind, placebo-lead in trial of TB MAS (12.5–37.5 mg/day); all participants received 2 weeks of single-blind placebo); one individual was a placebo responder and was discontinued. One of these 18 dropped after 1 week on 12.5 mg/day, while all others completed the trial and received 37.5 mg/day TB MAS.Results:There were significant effects of TB MAS on all clinical measures, including investigator overall symptoms (AISRS); self-report overall (ASRS), time-sensitive ADHD (TASS) scores throughout the day, impairment (CGI) and executive function scores (BRIEF-A). TB MAS was generally well tolerated.Conclusions:This study extends prior findings of TB MAS to adults with DSM-5 ADHD; it further re-validates findings of efficacy of TB MAS throughout the day.

中文翻译：

---

在 DSM-5 成人 ADHD 中进行三珠混合安非他明盐的单盲、安慰剂对照试验，全天评估效果

目的：检查三珠混合安非他明盐 (TB MAS) 对 DSM-5 ADHD 成人全天 ADHD 和执行功能障碍症状的影响。方法：这是一项为期 6 周的单盲安慰剂主导试验TB MAS（12.5–37.5 毫克/天）；所有参与者均接受 2 周的单盲安慰剂治疗）；一个人对安慰剂有反应，但被停药了。这 18 名患者中的一名在 1 周后停药，剂量为 12.5 毫克/天，而所有其他人完成试验并接受 37.5 毫克/天 TB MAS。 结果：TB MAS 对所有临床指标都有显着影响，包括研究者总体症状 (AISRS) ; 自我报告总体（ASRS）、全天时间敏感的多动症（TASS）评分、损伤（CGI）和执行功能评分（BRIEF-A）。TB MAS 通常具有良好的耐受性。结论：本研究将 TB MAS 的先前发现扩展到患有 DSM-5 ADHD 的成人；它进一步重新验证了 TB MAS 全天功效的发现。