We describe an unusual outbreak of mortality in suckling piglets following the misadministration of an oral vaccine against Salmonella Typhimurium and Salmonella Choleraesuis. Within 3–48 h of vaccination of a batch of ~700 piglets, ~300 developed marked swelling in the dorsal neck region, respiratory distress, fever, recumbency, and apathy. In total, ~100 died, and 4 were submitted for autopsy. Gross and microscopic lesions consisted of focally extensive areas of purple discoloration in the skin of the cervical region, associated with edema and hemorrhage in the subcutis and muscles. Additionally, there was interstitial pneumonia with marked interlobular edema and mild fibrinous pleuritis. Aerobic bacterial culture identified Salmonella Typhimurium (3 cases) and Salmonella Choleraesuis (1 case) in samples of skeletal muscle and lung and from pleural swab samples. Marked immunostaining against Salmonella spp. was observed in the skeletal muscle of the cervical region, as well as in blood vessels and macrophages from the lung, liver, spleen, and kidney. We concluded that inappropriate intramuscular administration of an oral vaccine against Salmonella resulted in septicemia and death in a batch of piglets.

中文翻译：

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因口服疫苗肌肉注射不当导致哺乳仔猪败血性沙门氏菌病

我们描述了由于错误施用针对鼠伤寒沙门氏菌和猪霍乱沙门氏菌的口服疫苗而导致哺乳仔猪死亡的异常爆发。一批约 700 头仔猪接种疫苗后 3-48 小时内，约 300 头仔猪出现背颈区域明显肿胀、呼吸困难、发烧、躺卧和冷漠。总共约有 100 人死亡，其中 4 人被送去尸检。肉眼和微观病变包括颈部皮肤局部广泛的紫色变色区域，与皮下组织和肌肉的水肿和出血有关。此外，还存在间质性肺炎，伴有明显的小叶间水肿和轻度纤维蛋白性胸膜炎。需氧细菌培养在骨骼肌和肺样本以及胸膜拭子样本中鉴定出鼠伤寒沙门氏菌（3 例）和猪霍乱沙门氏菌（1 例）。针对沙门氏菌的显着免疫染色。在颈部骨骼肌以及肺、肝、脾和肾的血管和巨噬细胞中观察到了这种现象。我们得出的结论是，不恰当的肌肉注射沙门氏菌口服疫苗导致一批仔猪败血症和死亡。