Contrast-induced nephropathy (CIN) is an acute renal complication that can occur after the use of iodinated contrast media. Remnant cholesterol (RC) is one of the markers of atherosclerotic cardiovascular disease risk. We evaluated the impact of RC on CIN and clinical outcomes after coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). Consecutive patients ( n = 3332) undergoing CAG and/or PCI were assessed in this retrospective study. Patients were divided into four groups based on baseline RC levels. In the quartile analysis, RC were associated with a higher risk of CIN, especially when RC ≤0.20 or ≥0.38 mmol/L ( P < .05). However, after adjustment, the association of RC with CIN was not significant. There was a significant correlation between RC and repeated revascularization in patients undergoing PCI ( P < .001) and driven primarily by the highest quartile level. After adjustment, this remained statistically significant (adjusted odds ratio (aOR) 4.06; 95% CI 2.10–7.87; P < .001). This is the first large study to show a possible association between RC and the risk of CIN after CAG and/or PCI; however, this finding was not further confirmed after adjustment. The complex clinical risk profile of patients, rather than RC itself, may contribute to the risk of CIN in this high-risk subgroup.

中文翻译：

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接受冠状动脉造影和/或经皮冠状动脉介入治疗的患者中残余胆固醇与造影剂肾病之间的关联

造影剂肾病 (CIN) 是一种急性肾脏并发症，可能在使用碘造影剂后发生。残余胆固醇（RC）是动脉粥样硬化性心血管疾病风险的标志之一。我们评估了 RC 对 CIN 以及冠状动脉造影 (CAG) 和/或经皮冠状动脉介入治疗 (PCI) 后临床结果的影响。这项回顾性研究对连续接受 CAG 和/或 PCI 的患者 (n = 3332) 进行了评估。根据基线 RC 水平将患者分为四组。在四分位数分析中，RC 与较高的 CIN 风险相关，特别是当 RC ≤0.20 或≥0.38 mmol/L 时（ P < .05）。但调整后，RC与CIN的相关性并不显着。在接受 PCI 的患者中，RC 与重复血运重建之间存在显着相关性 (P < .001)，并且主要由最高四分位水平驱动。调整后，这仍然具有统计学意义（调整后的比值比 (aOR) 4.06；95% CI 2.10–7.87；P < .001）。这是第一项大型研究，表明 RC 与 CAG 和/或 PCI 后发生 CIN 的风险之间可能存在关联；但这一发现在调整后并未得到进一步证实。患者复杂的临床风险状况，而不是 RC 本身，可能会导致这一高危亚组发生 CIN 的风险。