Objective:To review the existing literature on transcranial photobiomodulation (tPBM) treatment effects on Autism Spectrum Disorder (ASD), in search for an effective treatment of a symptom cluster identified largely by contributions from late Dr. Biederman who asserted that they frequently present with Attention Deficit Hyperactivity Disorder (ADHD).Method:A survey of two databases, PubMed and PsycINFO, for clinical trials reporting on tPBM treatment in ASD was performed. Identified manuscripts that met eligibility criteria were then reviewed.Results:Three original manuscripts reporting findings on a heterogenous group of study methods met the eligibility criteria. Despite the heterogenous nature of study designs, findings from all three studies reported tPBM treatment to be associated with improvements in ASD symptoms. No serious or treatment limiting adverse events were reported.Conclusions:A nascent body of research suggests further clinical studies investigating efficacy of tPBM in treatment of ASD symptoms should be supported.

中文翻译：

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约瑟夫·比德曼 (Joseph Biederman) 博士的不朽遗产：通过经颅光生物调节照亮解决注意力缺陷多动障碍中自闭症特征的道路

目的：回顾经颅光生物调节 (tPBM) 对自闭症谱系障碍 (ASD) 治疗效果的现有文献，寻找有效治疗症状群的方法，该症状群主要由已故 Biederman 博士的贡献确定，他声称这些症状经常表现出注意力集中缺陷性多动障碍 (ADHD)。 方法：对 PubMed 和 PsycINFO 两个数据库进行调查，以报告 tPBM 治疗 ASD 的临床试验。然后对符合资格标准的已确定手稿进行审查。结果：报告异质研究方法组发现结果的三篇原始手稿符合资格标准。尽管研究设计存在异质性，但所有三项研究的结果均报告 tPBM 治疗与 ASD 症状的改善相关。没有报告严重或限制治疗的不良事件。结论：一项新兴的研究表明，应该支持进一步的临床研究，调查 tPBM 在治疗自闭症谱系障碍症状方面的功效。