Idiosyncratic adverse events to phenytoin therapy, such as agranulocytosis and acute liver failure, though rare, may be life-threatening. Simultaneous occurrence of both adverse events is exceedingly rare; only two cases have been reported in the literature to date. We describe such a case in a 15-year-old girl. Prompt haematological and hepatic recovery occurred after discontinuation of the drug. Given the widespread use of phenytoin in seizure disorders, clinicians prescribing this drug should be aware of its potential complications. Early recognition can considerably improve outcomes.

中文翻译：

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“双重打击”：特异质苯妥英诱导的粒细胞缺乏症和急性肝功能衰竭在儿科患者中异常同时发生

苯妥英治疗的特殊不良事件，如粒细胞缺乏症和急性肝功能衰竭，虽然罕见，但可能危及生命。两种不良事件同时发生的情况极为罕见；迄今为止，文献中仅报道了两例。我们描述了一个 15 岁女孩的案例。停药后血液学和肝脏迅速恢复。鉴于苯妥英在癫痫症中的广泛使用，开这种药的临床医生应该意识到其潜在的并发症。早期识别可以显着改善结果。