COronaVIrus Disease-2019 (COVID-19) is associated with a hypercoagulable state. Intracardiac thrombosis is a potentially serious complication but has seldom been evaluated in COVID-19 patients. We assessed the incidence, associated factors, and outcomes of COVID-19 patients with intracardiac thrombosis. In 2020, COVID-19 inpatients were identified from the National Inpatient Sample (NIS) database. Data on clinical characteristics, intracardiac thrombosis, and adverse outcomes were collected. Multivariable logistic regression was used to identify factors associated with intracardiac thrombosis, in-hospital mortality, and morbidities. In 2020, 1,683,785 COVID-19 inpatients (mean age 63.8 years, 32.2% females) were studied. Intracardiac thrombosis occurred in 0.10% (1830) of cases. In-hospital outcomes included 13.2% all-cause mortality, 3.5% cardiovascular mortality, 2.6% cardiac arrest, 4.4% acute coronary syndrome (ACS), 16.1% heart failure, 1.3% stroke, and 28.3% acute kidney injury (AKI). Key factors for intracardiac thrombosis were congestive heart failure history and coagulopathy. Intracardiac thrombosis independently linked to higher risks of all-cause mortality (odds ratio [OR]: 3.32 (2.42–4.54)), cardiovascular mortality (OR: 2.95 (1.96–4.44)), cardiac arrest (OR: 2.04 (1.22–3.43)), ACS (OR: 1.62 (1.17–2.22)), stroke (OR: 3.10 (2.11–4.56)), and AKI (OR: 2.13 (1.68–2.69)), but not heart failure. While rare, intracardiac thrombosis in COVID-19 patients independently raised in-hospital mortality and morbidity risks.

中文翻译：

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COVID-19 住院患者心内血栓：全国范围内的发病率、预测因子和结果研究

2019 冠状病毒病 (COVID-19) 与高凝状态有关。心内血栓形成是一种潜在的严重并发症，但很少在 COVID-19 患者中进行评估。我们评估了患有心内血栓形成的 COVID-19 患者的发病率、相关因素和结果。2020 年，从国家住院患者样本 (NIS) 数据库中识别出了 COVID-19 住院患者。收集有关临床特征、心内血栓形成和不良结果的数据。使用多变量逻辑回归来确定与心内血栓形成、院内死亡率和发病率相关的因素。2020 年，我们对 1,683,785 名 COVID-19 住院患者（平均年龄 63.8 岁，32.2% 女性）进行了研究。0.10% (1830) 的病例发生心内血栓。院内结局包括 13.2% 全因死亡率、3.5% 心血管死亡率、2.6% 心脏骤停、4.4% 急性冠状动脉综合征 (ACS)、16.1% 心力衰竭、1.3% 中风和 28.3% 急性肾损伤 (AKI)。心内血栓形成的关键因素是充血性心力衰竭病史和凝血功能障碍。心内血栓形成与全因死亡风险较高（比值比 [OR]：3.32 (2.42–4.54)）、心血管死亡率（OR：2.95 (1.96–4.44)）、心脏骤停（OR：2.04 (1.22–3.43)）独立相关))、ACS（OR：1.62 (1.17–2.22)）、卒中（OR：3.10 (2.11–4.56)）和 AKI（OR：2.13 (1.68–2.69)），但不包括心力衰竭。尽管罕见，但 COVID-19 患者的心内血栓形成独立地增加了院内死亡率和发病风险。