This meta-analysis investigated the effect of time-restricted eating (TRE) as an economical lifestyle intervention for the prevention of metabolic syndrome and improving the related metabolic variables. The Cochrane library, MEDLINE, EMBASE, clinical trials, and other databases were searched for randomized controlled trials (RCTs). We included 22 RCTs (1004 participants, aged 18–75 years, including healthy subjects, prediabetes and overweight patients) designed to evaluate the effect of TRE on metabolic parameters. Body mass index (BMI) (-0.56 kg/m2, 95% CI: -1.00, -0.13, P < .01), fasting blood glucose (-1.74 mmol/L, 95% CI: -3.34, -0.14, P < .01), and body weight (-0.48 kg, 95% CI: -0.74, -0.22, P < .01) in the TRE intervention group were decreased to varying degrees compared with controls. In contrast, high-density lipoprotein cholesterol (HDL-C) levels were significantly increased in the TRE group compared with the control group ( P < .01). The change in waist circumference, blood pressure, triglycerides, low-density lipoprotein cholesterol (LDL-C), and total cholesterol did not vary markedly across the groups. In conclusion, this meta-analysis found a significant reduction in BMI, weight, and fasting glucose, as well as a rise in HDL-C level with TRE compared with control. TRE could be used as an adjuvant treatment for metabolic dysfunctions.

中文翻译：

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限时饮食对代谢稳态影响的系统回顾和荟萃分析

这项荟萃分析研究了限时饮食（TRE）作为一种经济的生活方式干预措施对预防代谢综合征和改善相关代谢变量的影响。在 Cochrane 图书馆、MEDLINE、EMBASE、临床试验和其他数据库中检索了随机对照试验 (RCT)。我们纳入了 22 项随机对照试验（1004 名参与者，年龄 18-75 岁，包括健康受试者、糖尿病前期和超重患者），旨在评估 TRE 对代谢参数的影响。体重指数 (BMI) (-0.56 公斤/米2，95% CI：-1.00，-0.13，P < .01），空腹血糖（-1.74 mmol/L，95% CI：-3.34，-0.14，P < .01）和体重（-0.48 kg） , 95% CI: -0.74, -0.22, P < .01)在TRE干预组中与对照组相比均有不同程度的降低。相反，与对照组相比，TRE 组的高密度脂蛋白胆固醇 (HDL-C) 水平显着升高 ( P < .01)。各组的腰围、血压、甘油三酯、低密度脂蛋白胆固醇（LDL-C）和总胆固醇的变化没有显着差异。总之，这项荟萃分析发现，与对照组相比，TRE 组的 BMI、体重和空腹血糖显着降低，HDL-C 水平升高。TRE 可用作代谢功能障碍的辅助治疗。