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Perfusion Pressure and the Histology of Brain Death: A Unique Case in an Infant Maintained on Life Support
Pediatric and Developmental Pathology ( IF 1.9 ) Pub Date : 2024-01-31 , DOI: 10.1177/10935266231223276
Meagan Chambers 1 , Gail Deutsch 2
Affiliation  

Brain death is a not uncommon phenomena in the adult and pediatric population. Most cases are removed from life support soon after brain death is declared. Less commonly, systemic perfusion is maintained by life support for some time after neurologic function stops. These cases present uncommon opportunities to explore the histology of necrosis and autolysis in the context of global hypoxic ischemic damage. Here, we describe the unusual case of an infant maintained on life support for 2 weeks after brain death was declared with an emphasis on the resulting gross and histologic findings including a discussion of their underlying physiology.

中文翻译:

灌注压和脑死亡的组织学:靠生命维持的婴儿的独特病例

脑死亡在成人和儿童群体中是一种并不罕见的现象。大多数病例在宣布脑死亡后不久就会停止生命支持。不太常见的是,在神经功能停止后一段时间内通过生命支持维持全身灌注。这些病例为探索全球缺氧缺血性损伤背景下坏死和自溶的组织学提供了难得的机会。在这里,我们描述了一个婴儿在宣布脑死亡后仍维持生命维持两周的不寻常病例,重点是由此产生的总体和组织学发现,包括对其潜在生理学的讨论。
更新日期:2024-01-31
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