We examined the association between comorbid conditions and mild cognitive impairment (MCI) in Native Hawaiians and Pacific Islanders (NHPI) ( n = 54). Cross-sectional, self-reported questionnaires were utilized to collect demographic, comorbid conditions, and MCI (via the AD8 index) data. Separate logistic regression models were conducted to investigate the relationship between comorbid conditions and MCI, adjusting for other covariates. We found significantly increased odds of MCI in those reporting high blood pressure (OR = 5.27; 95% CI: [1.36, 20.46]; p = 0.016), high cholesterol (OR = 7.30; 95% CI: [1.90, 28.14], p = 0.004), and prediabetes or borderline diabetes (OR = 4.53; 95% CI: [1.27, 16.16], p = 0.02) compared with those not reporting these respective conditions. These data show that hypertension, hypercholesterolemia, and prediabetes are associated with MCI in the NHPI community, suggesting that preventive strategies to reduce chronic conditions may also potentially slow cognitive decline in underrepresented/understudied NHPI.

中文翻译：

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合并症与夏威夷原住民和太平洋岛民的认知障碍有关

我们研究了夏威夷原住民和太平洋岛民 (NHPI) 的合并症与轻度认知障碍 (MCI) 之间的关联 (n = 54)。使用横断面自我报告问卷来收集人口统计、合并症和 MCI（通过 AD8 指数）数据。采用单独的逻辑回归模型来研究合并症与 MCI 之间的关系，并调整其他协变量。我们发现，报告高血压（OR = 5.27；95% CI：[1.36，20.46]；p = 0.016）、高胆固醇（OR = 7.30；95% CI：[1.90，28.14]、 p = 0.004），以及糖尿病前期或边缘性糖尿病（OR = 4.53；95% CI：[1.27, 16.16]，p = 0.02）与未报告这些病症的患者相比。这些数据表明，高血压、高胆固醇血症和糖尿病前期与 NHPI 群体中的 MCI 相关，这表明减少慢性病的预防策略也可能减缓代表性不足/研究不足的 NHPI 的认知能力下降。