The effects of electronic cigarettes (e-cigarettes) vapor on inflammation and mucin secretion on asthmatics remain insufficiently explored. This study investigated the effects of e-cigarette vapor on allergic inflammation, cytokine production, and MUC5AC/5B expression in murine asthma model. Airway hyperresponsiveness was significantly higher in the e-cigarette-exposed ovalbumin (OVA) sensitization group than in the control, e-cigarette exposure, and OVA sensitization groups. The e-cigarette-exposed OVA sensitization group showed significantly greater infiltration of inflammatory cells and Th2-mediated inflammatory cytokines (interleukin-4 and −5) compared to the control, e-cigarette exposure, and OVA sensitization groups. MUC5AC mucin levels were significantly elevated in the e-cigarette exposure, OVA sensitization, and e-cigarette-exposed OVA sensitization groups, whereas MUC5B mucin levels were significantly elevated in the OVA sensitization and e-cigarette-exposed OVA sensitization groups. The results may suggest that the exposure to e-cigarette vapor in an asthmatics promoted allergic inflammation and increased mucin secretion, ultimately leading to the exacerbation of asthma.

中文翻译：

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电子烟通过细胞因子诱导和小鼠哮喘模型中的 MUC5AC/5B 表达加剧过敏性炎症

电子烟蒸气对哮喘患者炎症和粘蛋白分泌的影响尚未得到充分研究。本研究调查了电子烟蒸汽对小鼠哮喘模型中过敏性炎症、细胞因子产生和 MUC5AC/5B 表达的影响。电子烟暴露卵清蛋白 (OVA) 致敏组的气道高反应性显着高于对照组、电子烟暴露组和 OVA 致敏组。与对照组、电子烟暴露组和 OVA 致敏组相比，电子烟暴露 OVA 致敏组的炎症细胞和 Th2 介导的炎症细胞因子（白介素-4 和 -5）的浸润显着增加。在电子烟暴露组、OVA致敏组和电子烟暴露OVA致敏组中，MUC5AC粘蛋白水平显着升高，而MUC5B粘蛋白水平在OVA致敏组和电子烟暴露OVA致敏组中显着升高。结果可能表明，哮喘患者接触电子烟蒸气会促进过敏性炎症并增加粘蛋白分泌，最终导致哮喘恶化。