Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. and studies link DEHP exposure to impaired hypothalamic-pituitary-ovarian s (HPO) axis function, alteration of steroid-hormone levels and dysregulation of their receptors, and changes in uterine morphophysiology. In addition, high urinary DEPH levels have been associated with several reproductive disorders in women, including endometriosis, fibromyoma, fetal growth restriction and pregnancy loss. These data suggest that DEHP may be involved in the pathophysiology of various female reproductive diseases. Therefore, exposure to these compounds should be considered a concern in clinician surveillance practices for women at reproductive age and should be regulated to protect their health and that of their progeny.

中文翻译：

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DEHP 暴露对女性生殖健康的影响：深入了解子宫影响

塑料中释放的多种内分泌干扰化合物，包括多氟烷基物质、双酚类、阻燃剂、邻苯二甲酸盐等，由于其高毒性而对人类健康产生重大影响。这篇综述讨论了邻苯二甲酸二(2-乙基己基)酯 (DEHP)（邻苯二甲酸酯家族中最常见的成员）对女性生殖的影响。研究表明，接触 DEHP 会导致下丘脑-垂体-卵巢 (HPO) 轴功能受损、类固醇激素水平改变、受体失调以及子宫形态生理学变化。此外，尿液中高 DEPH 水平与女性的多种生殖疾病有关，包括子宫内膜异位症、纤维肌瘤、胎儿生长受限和流产。这些数据表明DEHP可能参与多种女性生殖疾病的病理生理学。因此，在临床医生对育龄妇女的监测实践中，应考虑接触这些化合物，并应对其进行监管，以保护她们及其后代的健康。