Children and young people with epilepsy are at higher risk of mental health disorders and atypical neurodevelopmental outcomes compared to the general population. It is essential to detect such comorbidities early in children with epilepsy and provide appropriate interventions, to improve clinical outcomes. We aimed to identify and evaluate the measurement properties of Patient-Reported Outcome Measures (PROMs) that have been validated specifically to measure mental health and neurodevelopmental outcomes in children and/or young people with epilepsy. We searched Embase, Medline, and PsycINFO in May 2023 for relevant studies. Mental health was defined as psychological symptoms (e.g., anxiety, depression, psychosis) and/or behavioural difficulties (e.g., conduct disorders). Neurodevelopmental outcomes included neurodevelopmental disorder traits such as attention-deficit hyperactivity disorder (ADHD) and autistic spectrum disorders. We assessed methodological quality using Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidance. Twelve papers were identified that psychometrically evaluated 13 relevant PROMs (two epilepsy-specific, eleven generic). The appraisal of the PROMs was limited by the availability of only one or two published articles for each, and incomplete psychometric evaluations in some cases. The tool demonstrating the strongest evidence was The Neurological Disorders Depression Inventory-Epilepsy for Youth. The ADHD Rating Scale-IV and The Paediatric Symptom Checklist -17 demonstrated good evidence in favour of at least two measurement properties. This review identified only a small number of mental health and neurodevelopmental PROMs evaluated specifically in paediatric epilepsy. There is a need for further validation of mental health and neurodevelopmental PROMs in children with epilepsy.

中文翻译：

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癫痫儿童和青少年的心理健康和神经发育患者报告结果测量（PROM）：系统评价

与一般人群相比，患有癫痫的儿童和青少年患精神健康障碍和非典型神经发育结果的风险更高。必须尽早发现癫痫儿童的此类合并症并提供适当的干预措施，以改善临床结果。我们的目的是确定和评估患者报告结果测量（PROM）的测量特性，这些测量特性已经过专门验证，可用于测量癫痫儿童和/或青少年的心理健康和神经发育结果。我们于 2023 年 5 月在 Embase、Medline 和 PsycINFO 中检索了相关研究。心理健康被定义为心理症状（例如焦虑、抑郁、精神病）和/或行为困难（例如品行障碍）。神经发育结果包括神经发育障碍特征，例如注意力缺陷多动障碍（ADHD）和自闭症谱系障碍。我们使用基于共识的健康测量工具选择标准 (COSMIN) 指南评估了方法学质量。确定了 12 篇论文，对 13 个相关 PROM 进行了心理测量评估（其中 2 篇针对癫痫，11 篇针对一般）。对 PROM 的评估受到限制，因为每个 PROM 只能发表一两篇文章，并且在某些情况下心理测量评估不完整。展示最有力证据的工具是青少年神经疾病抑郁量表-癫痫。 ADHD 评定量表-IV 和儿科症状检查表-17 证明了有利于至少两个测量特性的良好证据。该综述仅确定了少数专门针对小儿癫痫进行评估的心理健康和神经发育 PROM。需要进一步验证癫痫儿童的心理健康和神经发育 PROM。