Post-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care. To determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH). A cross-sectional study was conducted among 333 study participants between March 2021 and February 2022. Socio-demographic, clinical laboratory factors and anti-seizure medications were collected using a study questionnaire. Data was analysed to determine the prevalence of PTS and factors associated with occurrence of PTS among patients with DSF. The mean age (±SD) of study participants was 31.2, (±10.5) years, with a male to female ratio of 10.4:1. Nearly half of the study participants had attained secondary level of education, while 31.6 % (105) were peasants (subsistence farmers). The overall prevalence of PTS among DSF study participants was 16.2 % (54participants). Late presentation of PTS was the highest at 9.0 % (30) followed by early PTS at 3.9 % and immediate PTS at 3.3 % . Moderate Glasgow coma score (GCS: 9–13), p < 0.015, severe traumatic brain injury (GCS: 3–8), p < 0.026 at the time of admission and midline brain shift (≥5mm), p < 0.009 were associated with PTS. Phenytoin (94.3 %) was the most commonly used ASM followed by phenobarbitone (1.4 %) and Valproate (1.1 %) among study participants. Patients with moderate and severe traumatic brain injury and midline brain shift were associated with post traumatic seizures. Early identification and intervention may reduce the burden of posttraumatic seizures in this category of patients.

中文翻译：

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穆拉戈国家转诊医院颅骨凹陷性骨折成年患者的创伤后癫痫发作和相关因素；横断面研究

创伤后癫痫发作 (PTS) 在颅骨凹陷骨折 (DSF) 患者中很常见。了解 DSF 成年患者创伤后癫痫发作的负担以及相关因素对于改善临床护理非常重要。旨在确定穆拉戈国家转诊医院 (MNRH) 成年 DSF 患者中与创伤后癫痫发作相关的患病率和相关因素。2021 年 3 月至 2022 年 2 月期间，对 333 名研究参与者进行了一项横断面研究。通过研究问卷收集了社会人口统计学、临床实验室因素和抗癫痫药物。分析数据以确定 DSF 患者中 PTS 的患病率以及与 PTS 发生相关的因素。研究参与者的平均年龄 (±SD) 为 31.2 (±10.5) 岁，男女比例为 10.4:1。近一半的研究参与者受过中等教育，而 31.6%（105 人）是农民（自给自足的农民）。DSF 研究参与者中 PTS 的总体患病率为 16.2%（54 名参与者）。晚期出现 PTS 的比例最高，为 9.0% (30)，其次是早期 PTS，为 3.9%，即时 PTS 为 3.3%。中度格拉斯哥昏迷评分 (GCS: 9–13), p < 0.015, 入院时严重创伤性脑损伤 (GCS: 3–8), p < 0.026 和中线脑移位 (≥5mm), p < 0.009 相关与PTS。研究参与者中最常用的 ASM 是苯妥英 (94.3 %)，其次是苯巴比妥 (1.4 %) 和丙戊酸钠 (1.1 %)。中度和重度创伤性脑损伤和中线脑移位的患者与创伤后癫痫发作有关。早期识别和干预可能会减轻此类患者创伤后癫痫发作的负担。